Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

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http://www.wikidata.org/entity/Q29307422
Cancer wars: natural products strike backDesoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.Subcellular distribution of epothilones in human tumor cells.A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice.The antibody catalysis route to the total synthesis of epothilones.Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones.Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives.The 12,13-diol cyclization approach for a truly stereocontrolled total synthesis of epothilone B and the synthesis of a conformationally restrained analogue.A comparison of signaling activities induced by Taxol and desoxyepothilone B.Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes.Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).
P2860

Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

Item
http://www.wikidata.org/entity/Q29307422
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
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1997年の論文
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1997年論文
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1997年論文
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1997年論文
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1997年論文
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1997年論文
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1997年论文
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Total Synthesis of(–)-Epothilo ...... lationships of the Epothilones
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Total Synthesis of(–)-Epothilo ...... lationships of the Epothilones
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Total Synthesis of(–)-Epothilo ...... lationships of the Epothilones
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Total Synthesis of(–)-Epothilo ...... lationships of the Epothilones
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Total Synthesis of(–)-Epothilo ...... lationships of the Epothilones
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Total Synthesis of(–)-Epothilo ...... lationships of the Epothilones
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Total Synthesis of(–)-Epothilo ...... lationships of the Epothilones
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