Camptothecins and Topoisomerase I; A Foot in the Door. Targeting the Genome Beyond Topoisomerase I with Camptothecins and Novel Anticancer Drugs; Importance of DNA Replication, Repair and Cell Cycle Checkpoints

Camptothecins and Topoisomerase I; A Foot in the Door. Targeting the Genome Beyond Topoisomerase I with Camptothecins and Novel Anticancer Drugs; Importance of DNA Replication, Repair and Cell Cycle Checkpoints

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http://www.wikidata.org/entity/Q29308218

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Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives.Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent manners First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks CRLX101 (formerly IT-101)-A Novel Nanopharmaceutical of Camptothecin in Clinical Development Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation.Iron chelators with topoisomerase-inhibitory activity and their anticancer applications.Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer CDK1 phosphorylates WRN at collapsed replication forks.Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines.Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition.Specific targeting to murine myeloma cells of Cyt1Aa toxin from Bacillus thuringiensis subspecies israelensis.Chemo-sensitisation of HeLa cells to etoposide by a benzoxazine in the absence of DNA-PK inhibition.Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.Effect of oxidative stress from nanoscale TiO2 particles on a Physarum polycephalum macroplasmodium under dark conditions.Mitosis is not a key target of microtubule agents in patient tumors.

P2860

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P2860

Camptothecins and Topoisomerase I; A Foot in the Door. Targeting the Genome Beyond Topoisomerase I with Camptothecins and Novel Anticancer Drugs; Importance of DNA Replication, Repair and Cell Cycle Checkpoints

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http://www.wikidata.org/entity/Q29308218

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2004 nî lūn-bûn

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2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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