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Mammalian sirtuins: biological insights and disease relevance

Mammalian sirtuins: biological insights and disease relevance

http://www.wikidata.org/entity/Q29614496

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SIRT2 as a Therapeutic Target for Age-Related Disorders Dietary restriction depends on nutrient composition to extend chronological lifespan in budding yeast Saccharomyces cerevisiae Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription Acetylation-dependent regulation of Skp2 function AROS has a context-dependent effect on SIRT1 SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase SIRT2 induces the checkpoint kinase BubR1 to increase lifespan A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator Hypoxia-inducible factors and the response to hypoxic stress SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells Chromatin regulation and genome maintenance by mammalian SIRT6 Epigenetics and aging Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health Sirtuins Link Inflammation and Metabolism Metaboloepigenetic Regulation of Pluripotent Stem Cells Potential Modulation of Sirtuins by Oxidative Stress Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug Response Sirt1 and the Mitochondria Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer Intracellular Mono-ADP-Ribosylation in Signaling and Disease Sirtuin 1 and sirtuin 3: physiological modulators of metabolism Sirtuins as regulators of metabolism and healthspan AMPK as a potential anticancer target - friend or foe?Regulation of metabolism: the circadian clock dictates the time Metabolic modulation of chromatin: implications for DNA repair and genomic integrity SIRT1 and SIRT2: emerging targets in neurodegeneration Mitochondrial biogenesis through activation of nuclear signaling proteins Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism Nutrient-sensing pathways and metabolic regulation in stem cells Sirtuins, metabolism, and DNA repair Molecular mechanism of extrinsic factors affecting anti-aging of stem cells

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Mammalian sirtuins: biological insights and disease relevance

http://www.wikidata.org/entity/Q29614496

description

2010 nî lūn-bûn

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2010 թուականին հրատարակուած գիտական յօդուած

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2010 թվականին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Mammalian sirtuins: biological insights and disease relevance

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Mammalian sirtuins: biological insights and disease relevance

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Mammalian sirtuins: biological insights and disease relevance

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ANNUREV.PATHOL.4.110807.092250

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Annual Reviews of Pathology – Mechanisms of Disease

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Mammalian sirtuins: biological insights and disease relevance

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Haigis MC

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Sinclair DA

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P2860

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

Sirtuins: Sir2-related NAD-dependent protein deacetylases

Sir2-independent life span extension by calorie restriction in yeast

Increased life span due to calorie restriction in respiratory-deficient yeast

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression

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