Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways - Wikidata - wikimedia - TriplyDB

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

http://www.wikidata.org/entity/Q29614619

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A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence The dynamic cilium in human diseases A complex of BBS1 and NPHP7 is required for cilia motility in zebrafish Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling Dissection of epistasis in oligogenic Bardet-Biedl syndrome Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1 Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos Nephrocystin-3 is required for ciliary function in zebrafish embryos Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia NEK1 mutations cause short-rib polydactyly syndrome type majewski The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4 Increased expression of secreted frizzled-related protein 4 in polycystic kidneys Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3 Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation Nephronophthisis Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome Wnt/beta-catenin signaling: components, mechanisms, and diseases The role of primary cilia in neuronal function The primary cilium as a cellular signaling center: lessons from disease Mechanisms of nephronophthisis and related ciliopathies Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL HEF1-dependent Aurora A activation induces disassembly of the primary cilium The cilia-regulated proteasome and its role in the development of ciliopathies and cancer Cilia in autophagy and cancer Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis A polycystin-centric view of cyst formation and disease: the polycystins revisited Cilia in vertebrate development and disease The kidney and planar cell polarity.Understanding ciliated epithelia: the power of Xenopus Wnt and planar cell polarity signaling in cystic renal disease Primary cilia in the developing and mature brain Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies Coordination of kidney organogenesis by Wnt signaling Spectrum of clinical diseases caused by disorders of primary cilia Compartments within a compartment: what C. elegans can tell us about ciliary subdomain composition, biogenesis, function, and disease Scrutinizing ciliopathies by unraveling ciliary interaction networks

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Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

http://www.wikidata.org/entity/Q29614619

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年论文

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Inversin, the gene product mut ...... between Wnt signaling pathways

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Inversin, the gene product mut ...... between Wnt signaling pathways

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Inversin, the gene product mut ...... between Wnt signaling pathways

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Inversin, the gene product mut ...... between Wnt signaling pathways

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Inversin, the gene product mut ...... between Wnt signaling pathways

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Inversin, the gene product mut ...... between Wnt signaling pathways

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Nature Genetics

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Inversin, the gene product mut ...... between Wnt signaling pathways

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Andreas Jenny

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Athina Ganner

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Axel Bullerkotte

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Bozena Polok

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Corinna Krönig

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Mikhail Bashkurov

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Olga A Cabello

http://www.w3.org/2001/XMLSchema#string

P2860

Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells.

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction

Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos

Frizzled6 controls hair patterning in mice

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

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537-543

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868653

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10.1038/NG1552

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5

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37

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Bernhard Schermer

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2005-04-24T00:00:00Z

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7885908

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1038593550

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15852005

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3733333

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