Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain - Wikidata - wikimedia - TriplyDB

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

http://www.wikidata.org/entity/Q29615210

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The blooming of the French lilac Role of AMP-activated protein kinase in mechanism of metformin action Repurposing metformin: an old drug with new tricks in its binding pockets Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Molecular mechanism of action of metformin: old or new insights?Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore Metformin activates AMP kinase through inhibition of AMP deaminase Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing Pharmacogenetic studies update in type 2 diabetes mellitus Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders Fundamentals of cancer metabolism AMPK activators: mechanisms of action and physiological activities Regulation of AMP-activated protein kinase by natural and synthetic activators Current understanding of metformin effect on the control of hyperglycemia in diabetes Energy disruptors: rising stars in anticancer therapy?Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity Biochemical Genetic Pathways that Modulate Aging in Multiple Species New mechanisms of metformin action: Focusing on mitochondria and the gut Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets Targeting LKB1 in cancer - exposing and exploiting vulnerabilities Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells Mitohormesis AMP-activated protein kinase: a target for drugs both ancient and modern AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium AMPK: a target for drugs and natural products with effects on both diabetes and cancer Mitochondria as a therapeutic target in heart failure Old drug, new trick: repurposing metformin for gynecologic cancers?Cellular and molecular mechanisms of metformin: an overview AMPK: An emerging target for modification of injury-induced pain plasticity.New promises for metformin: advances in the understanding of its mechanisms of action Targeting mitochondria metabolism for cancer therapy FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer.Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy The emerging role of AMPK in the regulation of breathing and oxygen supply Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk

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P2860

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

http://www.wikidata.org/entity/Q29615210

description

2000 nî lūn-bûn

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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հունիսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Evidence that metformin exerts ...... itochondrial respiratory chain

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Evidence that metformin exerts ...... itochondrial respiratory chain

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Evidence that metformin exerts ...... itochondrial respiratory chain

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Evidence that metformin exerts ...... itochondrial respiratory chain

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Evidence that metformin exerts ...... itochondrial respiratory chain

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Evidence that metformin exerts ...... itochondrial respiratory chain

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Doran E

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Halestrap AP

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Owen MR

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P2860

Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

Biguanide-associated lactic acidosis. Case report and review of the literature.

Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition.

Biguanides. A review of history, pharmacodynamics and therapy.

The mechanism of action of phenformin in starved rats.

Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.

Energetics of Ehrlich ascites mitochondria: membrane potential of isolated mitochondria and mitochondria within digitonin-permeabilized cells.

Effects of metformin treatment on glucose transporter proteins in subcellular fractions of skeletal muscle in (fa/fa) Zucker rats

Evidence that the flux control coefficient of the respiratory chain is high during gluconeogenesis from lactate in hepatocytes from starved rats. Implications for the hormonal control of gluconeogenesis and action of hypoglycaemic agents

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348 Pt 3

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