Chimeric nucleases stimulate gene targeting in human cells
about
Flowing through the CRISPR-CAScade: Will genome editing boost cell therapies?Genome engineering using the CRISPR-Cas9 systemHuman SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaksImproved methods for the generation of human gene knockout and knockin cell linesZinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cellsComputational redesign of endonuclease DNA binding and cleavage specificityEfficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleasesTargeting DNA With Fingers and TALENsZinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleasesTargeting DNA double-strand breaks with TAL effector nucleasesMultiplex genome engineering using CRISPR/Cas systemsPrecision editing of large animal genomesNewer gene editing technologies toward HIV gene therapyFacile methods for generating human somatic cell gene knockouts using recombinant adeno-associated virusesGene targeting in the rat: advances and opportunitiesTherapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificitiesTargeted gene inactivation in zebrafish using engineered zinc-finger nucleasesRapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modificationHigh-frequency modification of plant genes using engineered zinc-finger nucleasesZinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cellsA combinatorial approach to create artificial homing endonucleases cleaving chosen sequencesHoming endonuclease mediated gene targeting in Anopheles gambiae cells and embryosHighly specific zinc finger proteins obtained by directed domain shuffling and cell-based selectionPotentiation of gene targeting in human cells by expression of Saccharomyces cerevisiae Rad52Human induced pluripotent stem cells for monogenic disease modelling and therapyCustomizing the genome as therapy for the β-hemoglobinopathiesThe Rise of CRISPR/Cas for Genome Editing in Stem CellsGenome-editing Technologies for Gene and Cell TherapyNuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome EditingTowards a new era in medicine: therapeutic genome editingBeyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogationNeuroprotective therapies in glaucoma: II. Genetic nanotechnology toolsOrigins of Programmable Nucleases for Genome EngineeringMinimizing off-Target Mutagenesis Risks Caused by Programmable NucleasesEnabling functional genomics with genome engineeringDesigned nucleases for targeted genome editingProtein design: toward functional metalloenzymesGene therapy for skin diseasesSynthetic biology in mammalian cells: next generation research tools and therapeuticsMaking designer mutants in model organisms
P2860
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P2860
Chimeric nucleases stimulate gene targeting in human cells
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Chimeric nucleases stimulate gene targeting in human cells
@ast
Chimeric nucleases stimulate gene targeting in human cells
@en
type
label
Chimeric nucleases stimulate gene targeting in human cells
@ast
Chimeric nucleases stimulate gene targeting in human cells
@en
prefLabel
Chimeric nucleases stimulate gene targeting in human cells
@ast
Chimeric nucleases stimulate gene targeting in human cells
@en
P3181
P356
P1433
P1476
Chimeric nucleases stimulate gene targeting in human cells
@en
P2093
Baltimore D
Porteus MH
P3181
P356
10.1126/SCIENCE.1078395
P407
P577
2003-05-02T00:00:00Z