Sequence variations in PCSK9, low LDL, and protection against coronary heart disease - Wikidata - wikimedia - TriplyDB

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

http://www.wikidata.org/entity/Q29616310

about

Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study Low carbohydrate versus isoenergetic balanced diets for reducing weight and cardiovascular risk: a systematic review and meta-analysis A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease Managing risks in drug discovery: reproducibility of published findings Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH Self-association of human PCSK9 correlates with its LDLR-degrading activity Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels Common variants at 30 loci contribute to polygenic dyslipidemia Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease The PCSK9 decade A map of human genome variation from population-scale sequencing Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates A common allele on chromosome 9 associated with coronary heart disease Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels Recent advances in pathogenesis, assessment, and treatment of atherosclerosis From proprotein convertase subtilisin/kexin type 9 to its inhibition: state-of-the-art and clinical implications Unmet Needs in LDL-C Lowering: When Statins Won't Do!PCSK9 inhibition in the management of hyperlipidemia: focus on evolocumab The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction Genetics of coronary artery disease and myocardial infarction Application of computational methods in genetic study of inflammatory bowel disease New developments in atherosclerosis: clinical potential of PCSK9 inhibition Hypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9 Insights into blood lipids from rare variant discovery Cardiovascular pharmacogenomics: current status and future directions Familial hypercholesterolemia: present and future management Benefits & risks of statin therapy for primary prevention of cardiovascular disease in Asian Indians - a population with the highest risk of premature coronary artery disease & diabetes New therapeutic principles in dyslipidaemia: focus on LDL and Lp(a) lowering drugs

P2860

Q21090089-9A3DBBB1-C7D5-4721-A618-8A702147E548 Q21132002-34D96A47-0594-481B-ABE9-498BD6FFB4D3 Q21136366-A600BB38-95D4-40B9-BB63-4FFB39134D7A Q21563383-D6F8732F-76D2-4B56-B75F-5417D31E79A5 Q24187425-E960BA82-927B-4846-9D6B-16321608F554 Q24289508-90A03CBD-A17D-4477-A76D-202F48D46D27 Q24294486-C11E7744-3076-4F6A-88E5-381C80BC4FF5 Q24297165-9F87852C-C7B6-44AE-B0A7-718AF26A9DA5 Q24306591-42E47D48-F059-4664-A2EF-00B560466670 Q24311328-4EFA1165-D6B9-4C50-A225-AF4B551C83FA Q24312859-FD861D04-651D-459C-AA9D-CDE123D4E63C Q24313575-7DA61D76-7D08-4455-9F8D-FD6EB68D55EC Q24598765-42B017C1-7D4F-4A75-9F08-BB88D8421AB7 Q24601772-4DCBC1F5-4FCD-46D6-A090-E3310CD298AC Q24615397-998924FA-B0DB-417E-97CD-6B08FE6A431F Q24617794-555665AB-337C-4649-979F-2A9B0E2977EB Q24643492-D516F3AF-3C94-4FF5-A9C0-06C1CA69341A Q24645076-9D6C7331-BFF6-4632-A973-3480EBC2EF4E Q24645376-D9CE60C3-7D5B-408F-BE8A-39C045826AB3 Q24646644-A5684B40-F8A7-4833-AAA1-E3B397278382 Q24647989-66CAA1D6-3996-410B-8F0A-45A623E6CB28 Q24649155-C27B7014-6273-40A3-856D-045607552159 Q24656975-B3C77B59-B688-45DF-8FB4-90DCAC6EA7DA Q24657931-547B76BA-59A1-46A5-99EA-DE55EDC5C1D5 Q24658351-5A357E36-BD71-4F21-8720-5D451ADFF672 Q26740304-5615A50F-7648-46E4-B5CA-66884B0EB368 Q26741078-B1C7A756-3C4E-4D08-A18F-F6F5E1CBD11C Q26741705-D6A85B31-97F1-440B-B202-3F42B58044B0 Q26747776-A5B419CB-B259-4C35-BE3A-DD311E92590C Q26748869-F52BCD8C-8464-4475-AC2F-5066D8782610 Q26752950-2400B212-669C-4E67-98AA-BF5D4F0CF932 Q26769994-EB5FEDC7-92B3-4C3B-AD07-DB3592215BA0 Q26774595-70950347-EA54-4FE3-91CD-031524C74757 Q26783407-40B14E04-A82D-4791-864A-BECC62CF59F4 Q26786549-165EC520-5656-4C79-AC38-D7AADDA328D8 Q26799138-F4B74E8E-9E03-475F-A150-FFBE4959EAFB Q26801183-9B9237B9-893E-480A-9FBE-71FCC76138E1 Q26828489-1A96D087-5DD4-47C5-9769-626D567D180B Q26853571-AB01CB76-86D8-491E-958A-BE4E293DE72C Q26863369-DDDC2938-EB20-46EC-87C2-BFB36ABD012F

P2860

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

http://www.wikidata.org/entity/Q29616310

description

2006 nî lūn-bûn

@nan

2006 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մարտին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

@ast

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

@en

type

label

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

@ast

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

@en

prefLabel

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

@ast

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

@en

P1433

Q29616310-D57DBF87-A40F-4964-880E-DADF158F2D1B

P1476

Q29616310-7FFAB9E8-CAAB-4928-A559-A5C7613AA189

P2093

Q29616310-69DF4F60-7DE8-40A0-A8EF-A6DC31787845

Q29616310-6C5E0832-7A70-41F6-B453-D6D75D39D1AB

Q29616310-9192B71E-156B-4CE9-9E38-6D18216A970F

Q29616310-AE895A5F-4AD3-4A68-A94E-DACCC9BFAC21

P304

Q29616310-342FE7B2-19A8-4386-AC56-CA3891B7D7B9

P31

Q29616310-F9F97C37-6ED7-45FD-8E59-BAD504611015

P3181

Q29616310-DC02318F-FD34-4850-8769-1217EEBE9E15

P356

Q29616310-CA1D6D8E-1A60-4ED3-BC39-4C4C4D5D7936

P407

Q29616310-EBC46C31-846E-43DE-B4CA-0A6115BF0756

P433

Q29616310-D9765E42-BB4B-4D20-B6C5-29F6AE8815C9

P478

Q29616310-17FB4619-E081-49E4-8478-9B4A22906A33

P577

Q29616310-D7D01EC2-2204-4B9D-927D-3D637996CC5E

P698

Q29616310-31C14355-01B1-452B-BE2E-61FAA2F9A72A

P3181

P356

P1433

The New England Journal of Medicine

P1476

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

@en

P2093

Boerwinkle E

http://www.w3.org/2001/XMLSchema#string

Cohen JC

http://www.w3.org/2001/XMLSchema#string

Hobbs HH

http://www.w3.org/2001/XMLSchema#string

Mosley TH Jr

http://www.w3.org/2001/XMLSchema#string

P304

1264-72

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

412027

http://www.w3.org/2001/XMLSchema#string

P356

10.1056/NEJMOA054013

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

354

http://www.w3.org/2001/XMLSchema#string

P577

2006-03-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16554528

http://www.w3.org/2001/XMLSchema#string