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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

http://www.wikidata.org/entity/Q29616494

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Yersinia controls type III effector delivery into host cells by modulating Rho activity Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin RhoA as a mediator of clinically relevant androgen action in prostate cancer cells ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.PTPmu suppresses glioma cell migration and dispersal Rho GTPases in hematopoiesis and hemopathies In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo Structural Mechanisms and Drug Discovery Prospects of Rho GTPases Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?Modulation of actin dynamics by Rac1 to target cognitive function Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Function and regulation of the Rho guanine nucleotide exchange factor Trio Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia The universally conserved prokaryotic GTPases Spontaneous and electric field-controlled front-rear polarization of human keratinocytes Collective motion of cells mediates segregation and pattern formation in co-cultures A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects Anisotropic stress orients remodelling of mammalian limb bud ectoderm.Involvement of local lamellipodia in endothelial barrier function Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis Novel allosteric sites on Ras for lead generation Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.Haemodynamics-driven developmental pruning of brain vasculature in zebrafish Rac activation by the T-cell receptor inhibits T cell migration A polarised population of dynamic microtubules mediates homeostatic length control in animal cells Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)Rac1-dependent lamellipodial motility in prostate cancer PC-3 cells revealed by optogenetic control of Rac1 activity Computational analysis of the spatiotemporal coordination of polarized PI3K and Rac1 activities in micro-patterned live cells Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors African swine fever virus uses macropinocytosis to enter host cells

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P2860

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

http://www.wikidata.org/entity/Q29616494

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Dickerson JB

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Gao Y

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Guo F

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Zheng J

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P2860

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

Rho GTPases in cell biology

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors

Dbl family guanine nucleotide exchange factors

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

Rho GTPases and signaling networks

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