An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer - Wikidata - wikimedia - TriplyDB

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

http://www.wikidata.org/entity/Q29616732

about

The NEDD8 modification pathway in plants Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8 Active site remodelling accompanies thioester bond formation in the SUMO E1 Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes Specific small molecule inhibitors of Skp2-mediated p27 degradation Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence Systematic and quantitative assessment of the ubiquitin-modified proteome Identifying druggable disease-modifying gene products Control of cell growth by the SCF and APC/C ubiquitin ligases The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions Cullin-RING ligases in regulation of autophagy Drugging the undruggables: exploring the ubiquitin system for drug development SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all Neutrophils and inflammatory resolution in the mucosa Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads When ubiquitin meets NF-κB: a trove for anti-cancer drug development Regulation of Unperturbed DNA Replication by Ubiquitylation Targeting the ubiquitin pathway for cancer treatment Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy Modification by ubiquitin-like proteins: significance in apoptosis and autophagy pathways Genomic instability in cancer.Building and remodelling Cullin-RING E3 ubiquitin ligases Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Dynamic ubiquitination drives herpesvirus neuroinvasion Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin Actions of adenosine on cullin neddylation: implications for inflammatory responses

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P2860

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

http://www.wikidata.org/entity/Q29616732

description

2009 nî lūn-bûn

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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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type

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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prefLabel

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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Adhikari S

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Berger AJ

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Bolen JB

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Brownell JE

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Burke KE

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Cardin DP

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Claiborne CF

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Critchley S

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Cullis CA

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10.1038/NATURE07884

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