Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
about
Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregationEvidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelityThe human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora BPharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageSpatio-temporal composition of the mitotic Chromosomal Passenger Complex detected using in situ proximity ligation assayCyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosisHuman NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachmentThe human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motilityHistone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.Genome stability is ensured by temporal control of kinetochore-microtubule dynamicsBuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignmentKinetochore-microtubule interactions: steps towards bi-orientationChromosomal instability and cancer: a complex relationship with therapeutic potentialTowards a quantitative understanding of mitotic spindle assembly and mechanicsPhosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochoreOrientation and structure of the Ndc80 complex on the microtubule lattice.KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebratesDeath receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphaseThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingRegulation of kinetochore-microtubule attachments through homeostatic control during mitosisMAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formationKNL1: bringing order to the kinetochoreReconstituting the kinetochore–microtubule interface: what, why, and howVisualizing kinetochore architectureFORMIN a link between kinetochores and microtubule endsSUMOylation in control of accurate chromosome segregation during mitosisStructural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior.Basic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules.Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Centromere protein F includes two sites that couple efficiently to depolymerizing microtubulesEB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule latticePhosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cellsKinetochore-independent chromosome poleward movement during anaphase of meiosis II in mouse eggsThe Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachmentThe Ndc80 kinetochore complex forms oligomeric arrays along microtubulesCENP-T provides a structural platform for outer kinetochore assembly
P2860
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P2860
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
@ast
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
@en
type
label
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
@ast
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
@en
prefLabel
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
@ast
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
@en
P2093
P3181
P1433
P1476
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
@en
P2093
P304
P3181
P356
10.1016/J.CELL.2006.09.047
P407
P577
2006-12-01T00:00:00Z