The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
about
Mapping interactions between mRNA export factors in living cellsCharacterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cellsTREX is a conserved complex coupling transcription with messenger RNA exportPurification and characterization of native spliceosomes suitable for three-dimensional structural analysis.Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein coreThe proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA exportATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complexProteins associated with the exon junction complex also control the alternative splicing of apoptotic regulatorsBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayeIF4A3 is a novel component of the exon junction complexRecruitment of the human TREX complex to mRNA during splicingFunctions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translationAdaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNAGrowth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNAMagoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexesSRm160 splicing coactivator promotes transcript 3'-end cleavageICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway.Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTDMutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.Proteomic analysis of interchromatin granule clustersA molecular link between SR protein dephosphorylation and mRNA exportThe spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctionsSplicing enhances translation in mammalian cells: an additional function of the exon junction complexA nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decayNuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1A natural allele of Nxf1 suppresses retrovirus insertional mutationsBasonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functionsLarge-scale proteomic analysis of the human spliceosomeALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancerStructure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processingDefining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains.Multiple Export Mechanisms for mRNAsDynamic integration of splicing within gene regulatory pathwaysChromatin and epigenetic regulation of pre-mRNA processingCoupling pre-mRNA processing to transcription on the RNA factory assembly lineRole of RNA helicases in HIV-1 replication
P2860
Q21133000-000CFDDD-E7FF-4499-8391-ED27967F44F3Q24293459-C81718E0-CED3-4127-8162-A051C079DF74Q24294319-8287EC4B-9752-4010-B7B3-CD0A8EB9310DQ24295211-C259B433-D640-4E4A-B4BD-DE0A87E5EFEEQ24296676-56985354-CD51-41EF-A4A2-F657C51209A8Q24297150-B8ADDBBD-2D30-43F0-8625-46C6CEF44A9EQ24297677-A8400D42-5551-4AD3-8523-F2041D278EC7Q24299834-BD8AA67E-18A4-4B4F-AEAC-25D78C46611BQ24300778-F849D166-285A-4665-951E-64434EF47E69Q24303422-2233BF24-ECC8-4F78-A883-B0354F148614Q24305305-9E6620EF-A52E-4B8F-AB10-08B588180B07Q24306879-82F861D8-B673-46F0-920A-CB396F485A88Q24315053-3D14FA87-25BD-4994-ADBF-9CCF7E4C5F6FQ24320299-DBFACDEA-2CFB-4374-B1C2-1DC4D79BFBAEQ24321750-58788E76-5D6F-4824-AFCA-A5C84511B086Q24336514-CB3EE655-DE00-48BB-9EE6-EE2E4EFF8296Q24535973-E4320B1C-2406-466D-B2F9-8253723F60BDQ24537105-E1DE10AC-17AF-4BE8-883D-336005B5E28AQ24538228-F082D3C6-4AA9-4ED4-A4E1-EC7C142A1080Q24538266-9233EB2A-2C38-4BD6-B598-03DC163B81FFQ24538841-C8886AA6-E3F1-4422-9FC2-CE565C202700Q24540125-23D5FBC2-A230-47E2-88E7-948537B9FD1EQ24541400-FACB07DA-5348-4200-93AF-3C01E257B4A2Q24561555-A589FDF8-5A66-4B60-98D7-ECCECA38D57FQ24561984-890B8236-A350-40FF-9AE9-172E03E39180Q24595096-C0D1C63F-67FB-4FE6-8B65-C7D6BDF53F22Q24623819-21AF67A0-F318-4CD5-BAE5-89EC3EEF1DD4Q24633921-23946257-450F-44B7-A821-67FEFD022459Q24652966-08B7F1F1-4166-4A4C-AEB8-3F6C2D8527D7Q24658176-8B66D066-A3C8-4AFB-9ACA-9AA842C3A60EQ24670168-B0BA2B68-0C40-4930-A5F0-867AB066DC3CQ24671785-0816C1C3-1F87-4CF5-9752-3318790203E9Q24672313-9D1ECF4F-ED0E-42B9-8E65-72806DEC8933Q24672665-CC4CDF05-D997-414B-8DCA-21C88FE22A55Q24682706-A8B5D26B-3179-4BB7-8803-B1EB6CB6FCD8Q26783595-8BE106C3-C096-462F-B0CC-5A6AAB6AEA89Q26852632-91D93BA0-EC2C-4591-84C6-C7CDE687FECFQ26999294-299EDCE8-FEF6-40DB-B4BF-BE64BAC9772AQ27024720-22052B56-0E69-4D9D-951B-CCE8397F15E2Q27477537-E27DBA89-5F97-4191-BC43-BA769BF7327E
P2860
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
@ast
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
@en
type
label
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
@ast
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
@en
prefLabel
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
@ast
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
@en
P2093
P356
P1433
P1476
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
@en
P2093
P2888
P356
10.1038/35030160
P407
P577
2000-09-21T00:00:00Z
P5875
P6179
1032325087