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The Concise Guide to PHARMACOLOGY 2013/14: overview.Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor.Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.Renal physiology of the extracellular calcium-sensing receptor.New concepts in calcium-sensing receptor pharmacology and signallingCalcium receptor-mediated intracellular signalling.Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism.Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones.Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways.The expression and function of Ca(2+)-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetesProtein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity.Increased receptor stimulation elicits differential calcium-sensing receptor(T888) dephosphorylation.Human calcium-sensing receptor can be suppressed by antisense sequences.Aminoglycosides increase intracellular calcium levels and ERK activity in proximal tubular OK cells expressing the extracellular calcium-sensing receptor.Phospholipase D-induced phosphatidate production in intact small arteries during noradrenaline stimulation: involvement of both G-protein and tyrosine-phosphorylation-linked pathways.Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats.Functional, molecular, and biochemical characterization of streptozotocin-induced diabetes.AQP2 is a substrate for endogenous PP2B activity within an inner medullary AKAP-signaling complex.Noradrenaline-induced paxillin phosphorylation, ERK activation and MEK-regulated contraction in intact rat mesenteric arteries.Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia.Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells.Short communication: urea transporter protein UT-B in the bovine parotid gland.Altered expression of iron transport proteins in streptozotocin-induced diabetic rat kidney.Extracellular calcium- and magnesium-mediated regulation of passive calcium transport across Caco-2 monolayers.Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.Disulfide bonds in the extracellular calcium-polyvalent cation-sensing receptor correlate with dimer formation and its response to divalent cations in vitro.Molecular and clinical analysis of a neonatal severe hyperparathyroidism case caused by a stop mutation in the calcium-sensing receptor extracellular domain representing in effect a human 'knockout'.Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells.Ca2+-sensing receptor induces Rho kinase-mediated actin stress fiber assembly and altered cell morphology, but not in response to aromatic amino acids.Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries.Dietary phosphate and parathyroid hormone alter the expression of the calcium-sensing receptor (CaR) and the Na+-dependent Pi transporter (NaPi-2) in the rat proximal tubule.Differential expression of divalent metal transporter DMT1 (Slc11a2) in the spermatogenic epithelium of the developing and adult rat testis.The inhibitory effect of simvastatin and aspirin on histamine responsiveness in human vascular endothelial cells.Increased endothelin-1 responsiveness in human coronary artery smooth muscle cells exposed to 1,25-dihydroxyvitamin D(3).Cellular localization of divalent metal transporter DMT-1 in rat kidney
P50
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P50
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physiologist
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wetenschapper
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D Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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D Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald Ward
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D Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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Donald T. Ward
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P106
P21
P31
P496
0000-0003-1342-9458