Intracellular mechanisms of molecular recognition and sorting for transport of large extracellular matrix molecules
about
Heat shock protein 47 and 65 KDa FK506 binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.TANGO1 assembles into rings around COPII coats at ER exit sites.The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta.TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.Protein sorting at the ER-Golgi interface.Regulation of the Sar1 GTPase Cycle Is Necessary for Large Cargo Secretion from the Endoplasmic Reticulum.Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia.New insights into protein secretion: TANGO1 runs rings around the COPII coat.Tango1 spatially organizes ER exit sites to control ER export.COPII-coated membranes function as transport carriers of intracellular procollagen I.Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology.4-PBA ameliorates cellular homeostasis in fibroblasts from osteogenesis imperfecta patients by enhancing autophagy and stimulating protein secretion.TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes.
P2860
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P2860
Intracellular mechanisms of molecular recognition and sorting for transport of large extracellular matrix molecules
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Intracellular mechanisms of mo ...... extracellular matrix molecules
@ast
Intracellular mechanisms of mo ...... extracellular matrix molecules
@en
type
label
Intracellular mechanisms of mo ...... extracellular matrix molecules
@ast
Intracellular mechanisms of mo ...... extracellular matrix molecules
@en
prefLabel
Intracellular mechanisms of mo ...... extracellular matrix molecules
@ast
Intracellular mechanisms of mo ...... extracellular matrix molecules
@en
P2093
P2860
P356
P1476
Intracellular mechanisms of mo ...... extracellular matrix molecules
@en
P2093
Hans Peter Bächinger
Kazuhiro Nagata
Lynn Y Sakai
Shinya Ito
Yoshihiro Ishikawa
P2860
P304
E6036-E6044
P356
10.1073/PNAS.1609571113
P407
P577
2016-09-27T00:00:00Z