Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.

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http://www.wikidata.org/entity/Q30010046
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's diseasePharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia.An integrated omics analysis: impact of microgravity on host response to lipopolysaccharide in vitro.Discovery and development of small molecule SHIP phosphatase modulators.Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.Common and Rare Genetic Variants Associated With Alzheimer's Disease.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity?Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia growth in a xenotransplantation mouse model.
P2860

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.

Item
http://www.wikidata.org/entity/Q30010046
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Leukemia-associated mutations ...... inactivate PI3K/AKT signaling.
@ast
Leukemia-associated mutations ...... inactivate PI3K/AKT signaling.
@en
type
label
Leukemia-associated mutations ...... inactivate PI3K/AKT signaling.
@ast
Leukemia-associated mutations ...... inactivate PI3K/AKT signaling.
@en
prefLabel
Leukemia-associated mutations ...... inactivate PI3K/AKT signaling.
@ast
Leukemia-associated mutations ...... inactivate PI3K/AKT signaling.
@en
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
Leukemia-associated mutations ...... inactivate PI3K/AKT signaling.
@en
P2093
P304
P31
P356
10.1016/J.CELLSIG.2012.07.017
P433
P478
P50
P577
P698