Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile

Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile

Item
http://www.wikidata.org/entity/Q30049453
Targeting purine and pyrimidine metabolism in human apicomplexan parasitesStructural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.Electrophilic aromatic selenylation: new OPRT inhibitors.Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.Malaria parasite carbonic anhydrase: inhibition of aromatic/heterocyclic sulfonamides and its therapeutic potential.A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish.An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparumPurine and pyrimidine pathways as targets in Plasmodium falciparum.Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free systemPyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum.Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferasesSynthesis of orotidine by intramolecular nucleosidation.Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase.
P2860

Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile

Item
http://www.wikidata.org/entity/Q30049453
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Human malaria parasite orotate ...... chanism and inhibition profile
@ast
Human malaria parasite orotate ...... chanism and inhibition profile
@en
type
label
Human malaria parasite orotate ...... chanism and inhibition profile
@ast
Human malaria parasite orotate ...... chanism and inhibition profile
@en
prefLabel
Human malaria parasite orotate ...... chanism and inhibition profile
@ast
Human malaria parasite orotate ...... chanism and inhibition profile
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Human malaria parasite orotate ...... chanism and inhibition profile
@en
P2093
P304
P31
P356
10.1016/J.MOLBIOPARA.2003.12.006
P407
P433
P478
P50
P577
P698
P921