about
Inequalities in health: the value of sex-related indicators.Collaborative development of predictive toxicology applications.OpenTox predictive toxicology framework: toxicological ontology and semantic media wiki-based OpenToxipedia.Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision MakingQSAR modeling: where have you been? Where are you going to?Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52In vitro cell transformation assays for an integrated, alternative assessment of carcinogenicity: a data-based analysis.Evaluation of the toxicity forecasting capability of EPA's ToxCast Phase I data: can ToxCast in vitro assays predict carcinogenicity?A data-based exploration of the adverse outcome pathway for skin sensitization points to the necessary requirements for its prediction with alternative methods.Correlation between gene expression and clinical data through linear and nonlinear principal components analyses: muscular dystrophies as case studies.Alternative strategies for carcinogenicity assessment: an efficient and simplified approach based on in vitro mutagenicity and cell transformation assays.Nonlinear signal analysis methods in the elucidation of protein sequence-structure relationships.Carcinogenicity of the aromatic amines: from structure-activity relationships to mechanisms of action and risk assessment.Designing safer drugs: (Q)SAR-based identification of mutagens and carcinogens.Putting the Predictive Toxicology Challenge into perspective: reflections on the results.The second National Toxicology Program comparative exercise on the prediction of rodent carcinogenicity: definitive results.Structure-activity relationship studies of chemical mutagens and carcinogens: mechanistic investigations and prediction approaches.Structure-activity models of chemical carcinogens: state of the art, and new directions.The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens.A novel approach: chemical relational databases, and the role of the ISSCAN database on assessing chemical carcinogenicity.Structure alerts for carcinogenicity, and the Salmonella assay system: a novel insight through the chemical relational databases technology.Alternatives to the carcinogenicity bioassay: in silico methods, and the in vitro and in vivo mutagenicity assays.Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology.Alternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet?Nongenotoxic carcinogenicity of chemicals: mechanisms of action and early recognition through a new set of structural alerts.Predicting the carcinogenicity of chemicals with alternative approaches: recent advances.Looking for an unambiguous geometrical definition of organic series from 3-d molecular similarity indices.Flexible use of QSAR models in predictive toxicology: a case study on aromatic amines.A comparative survey of chemistry-driven in silico methods to identify hazardous substances under REACH.Investigating the relationship between in vitro-in vivo genotoxicity: derivation of mechanistic QSAR models for in vivo liver genotoxicity and in vivo bone marrow micronucleus formation which encompass metabolism.Scientific opinion of Flavouring Group Evaluation 503 (FGE.503): grill flavour ‘Grillin’ CB‐200SF’Scientific opinion of Flavouring Group Evaluation 502 (FGE.502): grill flavour ‘Grillin’ 5078’Scientific Opinion on Flavouring Group Evaluation 73, Revision 4 (FGE.73Rev4): consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting) structurally related to primary saturated or unsatur...Scientific Opinion of Flavouring Group Evaluation 410 (FGE.410): 4’,5,7‐trihydroxyflavanone from chemical group 25 (phenol derivatives containing ring‐alkyl, ring‐alkoxy, and side‐chains with an oxygenated functional group)Safety of ethyl acrylate to be used as flavouringSafety of benzophenone to be used as flavouringPredictivity and reliability of QSAR models: the case of mutagens and carcinogens.Mechanistic QSAR of aromatic amines: new models for discriminating between homocyclic mutagens and nonmutagens, and validation of models for carcinogens.Simple and alpha,beta-unsaturated aldehydes: correct prediction of genotoxic activity through structure-activity relationship models.Assessment and validation of US EPA's OncoLogic® expert system and analysis of its modulating factors for structural alerts.
P50
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P50
description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
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Romualdo Benigni
@sl