Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia.
about
Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria.Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemiaHsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.Protein kinases: emerging therapeutic targets in chronic lymphocytic leukemia.HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimenThe novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy.Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy.MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL.Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Anti-cancer activity of withaferin A in B-cell lymphoma.Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLLCross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survivalp110δ PI3 kinase pathway: emerging roles in cancer.WDR5 high expression and its effect on tumorigenesis in leukemia.A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets.Human T-lymphotropic virus proteins and post-translational modification pathwaysHeat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignanciesSrc family kinases and their role in hematological malignancies.Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals.Lyn tyrosine kinase regulates androgen receptor expression and activity in castrate-resistant prostate cancer.Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells.MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinasesLeukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole.Lyn-mediated mitochondrial tyrosine phosphorylation is required to preserve mitochondrial integrity in early liver regeneration.HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment.Sorafenib targets BCR kinases and blocks migratory and microenvironmental survival signals in CLL cells.Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells.Hematopoietic lineage cell-specific protein 1 (HS1), a hidden player in migration, invasion, and tumor formation, is over-expressed in ovarian carcinoma cellsAbnormal regulation of BCR signalling by c-Cbl in chronic lymphocytic leukaemia
P2860
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P2860
Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Geldanamycin-induced Lyn disso ...... -chronic lymphocytic leukemia.
@ast
Geldanamycin-induced Lyn disso ...... -chronic lymphocytic leukemia.
@en
type
label
Geldanamycin-induced Lyn disso ...... -chronic lymphocytic leukemia.
@ast
Geldanamycin-induced Lyn disso ...... -chronic lymphocytic leukemia.
@en
prefLabel
Geldanamycin-induced Lyn disso ...... -chronic lymphocytic leukemia.
@ast
Geldanamycin-induced Lyn disso ...... -chronic lymphocytic leukemia.
@en
P2093
P50
P921
P1433
P1476
Geldanamycin-induced Lyn disso ...... -chronic lymphocytic leukemia.
@en
P2093
Cristina Gattazzo
Elena Tibaldi
Martina Frasson
Renato Zambello
P304
P356
10.1182/BLOOD-2008-02-139139
P407
P50
P577
2008-09-02T00:00:00Z