Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein.

Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein.

Item
http://www.wikidata.org/entity/Q30168772
Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathwayDepletion of the aryl hydrocarbon receptor in MDA-MB-231 human breast cancer cells altered the expression of genes in key regulatory pathways of cancerABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memoryThe NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence.NESH regulates dendritic spine morphology and synapse formation.Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.Abi1 gene silencing by short hairpin RNA impairs Bcr-Abl-induced cell adhesion and migration in vitro and leukemogenesis in vivo.Cancer-associated loss of TARSH gene expression in human primary lung cancer.NESH protein expression switches to the adverse effect of imatinib mesylate.Abi enhances Abl-mediated CDC2 phosphorylation and inactivation.Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease.
P2860

Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein.

Item
http://www.wikidata.org/entity/Q30168772
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Isolation and characterization ...... ecule similar to e3B1 protein.
@ast
Isolation and characterization ...... ecule similar to e3B1 protein.
@en
type
label
Isolation and characterization ...... ecule similar to e3B1 protein.
@ast
Isolation and characterization ...... ecule similar to e3B1 protein.
@en
prefLabel
Isolation and characterization ...... ecule similar to e3B1 protein.
@ast
Isolation and characterization ...... ecule similar to e3B1 protein.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Isolation and characterization ...... ecule similar to e3B1 protein.
@en
P2093
P304
P31
P356
10.1016/S0167-4781(00)00158-5
P407
P433
P478
P577
P698