Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases - Wikidata - wikimedia - TriplyDB

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

http://www.wikidata.org/entity/Q30278872

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New insights into the pathophysiology of achalasia and implications for future treatment Genetics and its potential to improve type 1 diabetes care.The MHC locus and genetic susceptibility to autoimmune and infectious diseases.Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci.Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders.Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases.Interactions within the MHC contribute to the genetic architecture of celiac disease Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis.Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma.Transancestral mapping and genetic load in systemic lupus erythematosus.Autoimmune comorbidity in achalasia patients.Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum.Introduction: MHC/KIR and governance of specificity.Immunogenomic approaches to understand the function of immune disease variants.Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.Fine mapping the MHC region identified four independent variants modifying susceptibility to chronic hepatitis B in Han Chinese.[Epidemiology and causes of Parkinson's disease].The Genetic Architecture of Type 1 Diabetes.dCATCH-Seq: improved sequencing of large continuous genomic targets with double-hybridization.Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.Cis-SNPs Set Testing and PrediXcan Analysis for Gene Expression Data using Linear Mixed Models.Genetic and environmental risk factors for rheumatoid arthritis.What has GWAS done for HLA and disease associations?Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.HLA variation and disease.Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis.Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and Phenotypic Correlates in Pediatric Steroid-Sensitive Nephrotic Syndrome Rheumatoid Arthritis-Associated Autoimmunity Due to and Its Resolution With Antibiotic Therapy

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Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

http://www.wikidata.org/entity/Q30278872

description

2015 nî lūn-bûn

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2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Widespread non-additive and in ...... he risk of autoimmune diseases

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Widespread non-additive and in ...... he risk of autoimmune diseases

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Widespread non-additive and in ...... he risk of autoimmune diseases

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Nature Genetics

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Widespread non-additive and in ...... he risk of autoimmune diseases

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Andre Franke

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Buhm Han

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Guy E Boeckxstaens

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Ines Gockel

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James T Elder

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Javier Gutierrez-Achury

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Jessica Becker

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Johannes Schumacher

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Michael Knapp

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Mira M Wouters

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MHC heterozygosity confers a selective advantage against multiple-strain infections.

The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses

Effect of human leukocyte antigen heterozygosity on infectious disease outcome: the need for allele-specific measures

Interrogating the major histocompatibility complex with high-throughput genomics

HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage

The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

Genetics and epigenetics of rheumatoid arthritis

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

The molecular basis of genetic dominance

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1085-1090

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10.1038/NG.3379

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9

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47

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Gonçalo Abecasis

Soumya Raychaudhuri

Jane Worthington

Suna Onengut-Gumuscu

Alexandra Zhernakova

Solbritt Rantapää-Dahlqvist

Dafna D. Gladman

Markus M Nöthen

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2015-08-10T00:00:00Z

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1018131274

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26258845

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