Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma - Wikidata - wikimedia - TriplyDB

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

http://www.wikidata.org/entity/Q30278895

about

EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor.Therapeutic applications of histone deacetylase inhibitors in sarcoma.Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma.Clinicopathologic implications of CD8(+)/Foxp3(+) ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients.Immunophenotypic features of dedifferentiated skull base chordoma: An insight into the intratumoural heterogeneity.Chordoma: The Quest for Better Treatment Options.

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Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

http://www.wikidata.org/entity/Q30278895

description

2015 nî lūn-bûn

@nan

2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

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Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

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type

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Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

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Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

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prefLabel

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

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Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

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JOURNAL.PONE.0134426

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Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

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Amin B Kassam

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Brian J Williams

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Craig Horbinski

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Dae-Hee Lee

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Daniel Prevedello

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Deric M Park

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Hussein Tawbi

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Mark E Shaffrey

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Merrill J Egorin

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Myung-Jin Park

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway

Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas

Pten dose dictates cancer progression in the prostate

Loss of PTEN facilitates HIF-1-mediated gene expression

Regulation of c-Met-dependent gene expression by PTEN

Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas

Pten is essential for embryonic development and tumour suppression

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

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e0134426

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scholarly article

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