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Combinatorial compound libraries for drug discovery: an ongoing challenge.

Combinatorial compound libraries for drug discovery: an ongoing challenge.

http://www.wikidata.org/entity/Q30310572

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When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis Discovery of active proteins directly from combinatorial randomized protein libraries without display, purification or sequencing: identification of novel zinc finger proteins Identifying the immunomodulatory components of helminths Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II Phage protein-targeted cancer nanomedicines.Microengineering methods for cell-based microarrays and high-throughput drug-screening applications Docking challenge: protein sampling and molecular docking performance.Estimation of the size of drug-like chemical space based on GDB-17 data.Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers.Fluorous-enhanced multicomponent reactions for making drug-like library scaffolds.Microwave-Enhanced High-Speed Fluorous Synthesis.Development of a fluorescence-based, ultra high-throughput screening platform for nanoliter-scale cytochrome p450 microarrays.Mutations in fd phage major coat protein modulate affinity of the displayed peptide High-throughput in vivo screening of targeted molecular imaging agents.'On-the-fly' optical encoding of combinatorial peptide libraries for profiling of protease specificity.The Privileged Chemical Space Predictor (PCSP): a computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries.A peptide & peptide nucleic acid synthesis technology for transporter molecules and theranostics--the SPPS.A sandwiched microarray platform for benchtop cell-based high throughput screening.Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses.High-throughput small molecule identification using MALDI-TOF and a nanolayered substrate.Microwave-assisted tandem transformation on an ionic-liquid support: efficient synthesis of pyrrolo/pyridobenzimidazolones and isoindolinone-fused benzimidazoles.Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery.Photo-assisted peptide enrichment in protein complex cross-linking analysis of a model homodimeric protein using mass spectrometry.Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale High-throughput enzyme assay on a multichannel microchip using optically gated sample introduction Microwave and continuous flow technologies in drug discovery.Towards microfluidic technology-based MALDI-MS platforms for drug discovery: a review.Biomedical engineering strategies in system design space.Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamides.Drug discovery in academia.Incorporating Virtual Reactions into a Logic-based Ligand-based Virtual Screening Method to Discover New Leads A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes.Screening of Small Molecule Microarrays for Ligands Targeted to the Extracellular Epitopes of Living Cells.Three-dimensional cellular microarray for high-throughput toxicology assays Control and detection of chemical reactions in microfluidic systems.High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research Systematizing serendipity for cardiovascular drug discovery.Molecules that modulate Apaf-1 activity.Advances in cell-based biosensors using three-dimensional cell-encapsulating hydrogels.Action of natural products on p2 receptors: a reinvented era for drug discovery.

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P2860

Combinatorial compound libraries for drug discovery: an ongoing challenge.

http://www.wikidata.org/entity/Q30310572

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2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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Combinatorial compound libraries for drug discovery: an ongoing challenge.

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Combinatorial compound libraries for drug discovery: an ongoing challenge.

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Nature Reviews Drug Discovery

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Combinatorial compound libraries for drug discovery: an ongoing challenge.

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David Wagner

http://www.w3.org/2001/XMLSchema#string

Frank Schoenen

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H Mario Geysen

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Richard Wagner

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P2860

Comprehensive survey of combinatorial library synthesis: 1998.

Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997.

Encoding methods for combinatorial chemistry.

Recent advances in the preparation of heterocycles on solid support: a review of the literature.

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

Isotope or mass encoding of combinatorial libraries.

Solid-phase organic reactions II: A review of the literature Nov 95–Nov 96

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222-230

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10.1038/NRD1035

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3

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2

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12612648

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