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Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and designPreference of small molecules for local minimum conformations when binding to proteinsABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gatingNovel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticidesParkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementaritySelective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne DiseasesCrystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triadCasp8p41 generated by HIV protease kills CD4 T cells through direct Bak activationPlasma butyrylcholinesterase regulates ghrelin to control aggressionConfigurational entropy in protein-peptide binding: computational study of Tsg101 ubiquitin E2 variant domain with an HIV-derived PTAP nonapeptideAccurate reproduction of 161 small-molecule complex crystal structures using the EUDOC program: expanding the use of EUDOC to supramolecular chemistryPotent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular designSmall molecules showing significant protection of mice against botulinum neurotoxin serotype AFF12MC: A revised AMBER forcefield and new protein simulation protocol.Atomic levers control pyranose ring conformations.Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors.Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.Novel acetylcholinesterase target site for malaria mosquito control.Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype ANormal-mode-analysis-monitored energy minimization procedure for generating small-molecule bound conformations.A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist.Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin.The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosinGenome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle.Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program.East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway.Common pharmacophore of structurally distinct small-molecule inhibitors of intracellular retrograde trafficking of ribosome inactivating proteins.Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's DiseaseBak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-OligomerizationCholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum.Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils.Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitinChemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteinsActivation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin.Use of multiple picosecond high-mass molecular dynamics simulations to predict crystallographic B-factors of folded globular proteins.Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets.
P50
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P50
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հետազոտող
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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Yuan-Ping Pang
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P106
P108
P1153
7201686083
P21
P31
P496
0000-0003-0838-2560