Ion mobility-mass spectrometry of intact protein--ligand complexes for pharmaceutical drug discovery and development.
about
Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksThe emerging role of native mass spectrometry in characterizing the structure and dynamics of macromolecular complexes.The diverse and expanding role of mass spectrometry in structural and molecular biologycAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometryResolution of protein structure by mass spectrometry.Quantifying the stabilizing effects of protein-ligand interactions in the gas phaseHuman defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.Kinetic intermediates of holo- and apo-myoglobin studied using HDX-TIMS-MS and molecular dynamic simulations.Enhancing bottom-up and top-down proteomic measurements with ion mobility separationsMass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platformQuantitative mass spectrometry methods for pharmaceutical analysis.Collidoscope: An Improved Tool for Computing Collisional Cross-Sections with the Trajectory Method.Chemical Probes and Engineered Constructs Reveal a Detailed Unfolding Mechanism for a Solvent-Free Multidomain Protein.Collisional unfolding of multiprotein complexes reveals cooperative stabilization upon ligand binding.Targeting transcription is no longer a quixotic questThe intrinsically disordered N-terminal arm of the brome mosaic virus coat protein specifically recognizes the RNA motif that directs the initiation of viral RNA replication.From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.Gas-Phase Analysis of the Complex of Fibroblast GrowthFactor 1 with Heparan Sulfate: A Traveling Wave Ion Mobility Spectrometry (TWIMS) and Molecular Modeling Study.IMTBX and Grppr: Software for Top-Down Proteomics Utilizing Ion Mobility-Mass Spectrometry.A Customizable Flow Injection System for Automated, High Throughput, and Time Sensitive Ion Mobility Spectrometry and Mass Spectrometry Measurements.Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry.Mass spectrometry based strategy for studies of binding sites and structural changes of cisplatin binding to myoglobin.Ion mobility coupled to native mass spectrometry as a relevant tool to investigate extremely small ligand-induced conformational changes.Direct monitoring of protein–protein inhibition using nano electrospray ionization mass spectrometry
P2860
Q26784027-9361CA20-F7DF-4EA2-8507-16AEEB78BA77Q26826822-42E6BE1D-7DE4-40EF-BC67-6B54DF2A220CQ28080243-D404FFA6-552D-47FC-8C00-6ADC7B432D97Q28822154-721C1C03-31AB-45C8-8907-61EE167DB081Q30370085-12F43337-741D-494A-A317-A43A6C97AC82Q30379986-619968D3-A717-4B86-94DE-8518F8AB0A74Q34727874-63A34F7E-8859-4AC6-BECF-B927B9AA1E78Q35471834-1897EBD0-816C-4661-8920-24463176F7D1Q35945797-77340AC6-62CD-449B-8DA0-DD2374684CFBQ36840082-ACC94BD2-9BB3-4C76-A1A9-A346A55045E1Q38958771-B2F3D62D-24A3-42AA-91BB-48B31B2CE7A9Q38962881-C2FC8E9D-D4DC-4033-B3EF-A5698AC18CF9Q39105512-F12B5D33-797F-452F-8C16-28D1AB4B0791Q40943345-84FB69B2-4C2E-4F49-B124-DFDF5FF9F2C3Q41552169-91BE88F7-24D4-4BFC-B85B-8E12234CE628Q45324821-6A856380-AC0D-4DC6-AE4D-4FB099CAEA93Q46522186-785A7C88-E052-4A9C-9FF9-BF76E3640902Q47148090-DBFE3718-180F-4A00-AF61-0A9B7819A216Q47248299-39524F76-C688-4EFC-967D-D3BC38FE6456Q47378519-632CEADF-1B53-41C7-8C59-1B2BA98CCA2FQ47662080-F2238686-048B-49C9-B2C9-F4C82984B0EAQ49041510-13D2BB58-3DC9-4F7A-8444-1E28CBDE5B3AQ49076691-4CF8573E-1742-4B57-9BFA-3DDE594D6F82Q53339732-DF491CC0-2A78-40F3-A451-931067D63066Q57825638-270C47B2-A3CE-4847-AA4B-AA91001C6716
P2860
Ion mobility-mass spectrometry of intact protein--ligand complexes for pharmaceutical drug discovery and development.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Ion mobility-mass spectrometry ...... rug discovery and development.
@ast
Ion mobility-mass spectrometry ...... rug discovery and development.
@en
type
label
Ion mobility-mass spectrometry ...... rug discovery and development.
@ast
Ion mobility-mass spectrometry ...... rug discovery and development.
@en
prefLabel
Ion mobility-mass spectrometry ...... rug discovery and development.
@ast
Ion mobility-mass spectrometry ...... rug discovery and development.
@en
P1476
Ion mobility-mass spectrometry ...... rug discovery and development.
@en
P2093
Jessica N Rabuck
P304
P356
10.1016/J.CBPA.2013.06.019
P577
2013-07-12T00:00:00Z