Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop.
about
A database of macromolecular motionsPredicting functional sites with an automated algorithm suitable for heterogeneous datasetsThe hitchhiker's guide to the voltage-gated sodium channel galaxyModeling, mutagenesis, and structural studies on the fully conserved phosphate-binding loop (loop 8) of triosephosphate isomerase: toward a new substrate specificityStructural determinants for ligand binding and catalysis of triosephosphate isomeraseOptimal alignment for enzymatic proton transfer: structure of the Michaelis complex of triosephosphate isomerase at 1.2-A resolution.Crystal structure of triosephosphate isomerase complexed with 2-phosphoglycolate at 0.83-A resolutionStructure of Plasmodium falciparum triose-phosphate isomerase-2-phosphoglycerate complex at 1.1-A resolutionEnzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selectionIncreasing the Conformational Entropy of the Ω-Loop Lid Domain in Phosphoenolpyruvate Carboxykinase Impairs Catalysis and Decreases Catalytic Fidelity,Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis--distal effects on dimer stabilityThe Crystal Structure Analysis of Group B Streptococcus Sortase C1: A Model for the “Lid” Movement upon Substrate BindingEnzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate IsomeraseProbing the role of highly conserved residues in triosephosphate isomerase--analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzymeConnecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial EnzymeThree-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamilyTriose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus. Kinetic and structural propertiesMolecular dynamics and protein function.Probing the flexibility of large conformational changes in protein structures through local perturbationsBackrub-like backbone simulation recapitulates natural protein conformational variability and improves mutant side-chain predictionDeconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus.Anomalies in the vibrational dynamics of proteins are a consequence of fractal-like structureComputer simulation of the triosephosphate isomerase catalyzed reaction.Structure of the dimeric N-glycosylated form of fungal beta-N-acetylhexosaminidase revealed by computer modeling, vibrational spectroscopy, and biochemical studies.Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations.Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion.Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O.Determination of the amino acid requirements for a protein hinge in triosephosphate isomerase.What's in your buffer? Solute altered millisecond motions detected by solution NMR.Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107Gating of the active site of triose phosphate isomerase: Brownian dynamics simulations of flexible peptide loops in the enzyme.The conformation of the active site of myosin probed using mant-nucleotides.The loop opening/closing motion of the enzyme triosephosphate isomerase1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK.Induced fit in arginine kinase.Analysis of functional motions in Brownian molecular machines with an efficient block normal mode approach: myosin-II and Ca2+ -ATPase.Intersubunit signaling in glutamate-1-semialdehyde-aminomutase.Enzyme architecture: optimization of transition state stabilization from a cation-phosphodianion pair.Molecular dynamics simulations of Trichomonas vaginalis ferredoxin show a loop-cap transitionConformational change in substrate binding, catalysis and product release: an open and shut case?
P2860
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P2860
Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop.
description
1990 nî lūn-bûn
@nan
1990 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
name
Anatomy of a conformational ch ...... riosephosphate isomerase loop.
@ast
Anatomy of a conformational ch ...... riosephosphate isomerase loop.
@en
type
label
Anatomy of a conformational ch ...... riosephosphate isomerase loop.
@ast
Anatomy of a conformational ch ...... riosephosphate isomerase loop.
@en
prefLabel
Anatomy of a conformational ch ...... riosephosphate isomerase loop.
@ast
Anatomy of a conformational ch ...... riosephosphate isomerase loop.
@en
P356
P1433
P1476
Anatomy of a conformational ch ...... riosephosphate isomerase loop.
@en
P2093
P304
P356
10.1126/SCIENCE.2402636
P407
P577
1990-09-01T00:00:00Z