Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin
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The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of InfluenzaAn MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient micePatterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutininSeasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian InfluenzaInfection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus.Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms.T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model.Coupling sensitive in vitro and in silico techniques to assess cross-reactive CD4(+) T cells against the swine-origin H1N1 influenza virus.Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection.Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus.A human CD4+ T cell epitope in the influenza hemagglutinin is cross-reactive to influenza A virus subtypes and to influenza B virus.Detection of site-specific positive Darwinian selection on pandemic influenza A/H1N1 virus genome: integrative approaches.Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challengeMixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cellsIdentification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses.Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope predictionAnalyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins.Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization.Peptide sharing between influenza A H1N1 hemagglutinin and human axon guidance proteins.Comparative glycomics analysis of influenza Hemagglutinin (H5N1) produced in vaccine relevant cell platforms.Profiling the humoral immune response of acute and chronic Q fever by protein microarray.The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infectionThe contribution of systemic and pulmonary immune effectors to vaccine-induced protection from H5N1 influenza virus infection.West Nile virus T-cell ligand sequences shared with other flaviviruses: a multitude of variant sequences as potential altered peptide ligandsThree-dimensional structure determines the pattern of CD4+ T-cell epitope dominance in influenza virus hemagglutinin.Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins.CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccinationProtection against lethal influenza with a viral mimic.Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus InfectionAbortive activation of CD4 T cell responses during competitive priming in vivoGenome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4(+) T-cell responses to internal proteins, hemagglutinins, and neuraminidases.In vitro responses to avian influenza H5 by human CD4 T cellsCD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer.The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity.Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses.Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection.CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential
P2860
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P2860
Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Direct ex vivo analyses of HLA ...... influenza virus hemagglutinin
@ast
Direct ex vivo analyses of HLA ...... influenza virus hemagglutinin
@en
type
label
Direct ex vivo analyses of HLA ...... influenza virus hemagglutinin
@ast
Direct ex vivo analyses of HLA ...... influenza virus hemagglutinin
@en
prefLabel
Direct ex vivo analyses of HLA ...... influenza virus hemagglutinin
@ast
Direct ex vivo analyses of HLA ...... influenza virus hemagglutinin
@en
P2093
P2860
P356
P1433
P1476
Direct ex vivo analyses of HLA ...... influenza virus hemagglutinin
@en
P2093
Andrea J Sant
Christopher A Lazarski
David J Topham
Francisco A Chaves
Frederick R Krafcik
Katherine A Richards
P2860
P304
P356
10.1128/JVI.02834-06
P577
2007-05-16T00:00:00Z