Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
about
Allosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulationsThe origin of minus-end directionality and mechanochemistry of Ncd motorsAllostery in the ferredoxin protein motif does not involve a conformational switchTrimming Down a Protein Structure to Its Bare Foldons: SPATIAL ORGANIZATION OF THE COOPERATIVE UNITStrain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor ActivityAn all-atom structure-based potential for proteins: bridging minimal models with all-atom empirical forcefields.Mining electron density for functionally relevant protein polysterism in crystal structures.Dimethyl sulfoxide induced structural transformations and non-monotonic concentration dependence of conformational fluctuation around active site of lysozyme.Frustration, specific sequence dependence, and nonlinearity in large-amplitude fluctuations of allosteric proteins.Single-molecule enzymatic conformational dynamics: spilling out the product molecules.The energy landscape analysis of cancer mutations in protein kinasesData-driven approach to decomposing complex enzyme kinetics with surrogate models.On the role of frustration in the energy landscapes of allosteric proteins.Frustration in biomoleculesStrand swapping regulates the iron-sulfur cluster in the diabetes drug target mitoNEETProtein frustratometer: a tool to localize energetic frustration in protein molecules.Disorder guides protein function.Biomolecular dynamics: order-disorder transitions and energy landscapesProtein functional landscapes, dynamics, allostery: a tortuous path towards a universal theoretical framework.Sizing up single-molecule enzymatic conformational dynamics.Probing single-molecule enzyme active-site conformational state intermittent coherence.Protein dynamics and function from solution state NMR spectroscopy.Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.Computational delineation of the catalytic step of a high-fidelity DNA polymerase.Protein folding pathways and state transitions described by classical equations of motion of an elastic network model.Why Ubiquitin Has Not Evolved.Probing protein multidimensional conformational fluctuations by single-molecule multiparameter photon stamping spectroscopy.The spectrum of biomolecular states and motions.Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.Manipulating and probing enzymatic conformational fluctuations and enzyme-substrate interactions by single-molecule FRET-magnetic tweezers microscopy.Diverse role of conformational dynamics in carboxypeptidase A-driven peptide and ester hydrolyses: disclosing the "perfect induced fit" and "protein local unfolding" pathways by altering protein stability.Sampling large conformational transitions: adenylate kinase as a testing ground
P2860
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P2860
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
@ast
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
@en
type
label
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
@ast
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
@en
prefLabel
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
@ast
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
@en
P2093
P2860
P356
P1476
Energy landscape along an enzymatic reaction trajectory: hinges or cracks?
@en
P2093
José Nelson Onuchic
Paul Charles Whitford
Peter Guy Wolynes
P2860
P356
10.2976/1.2894846
P577
2008-03-24T00:00:00Z