A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.
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Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A(H1N1)pdm09 influenza virusesMolecular epidemiology of influenza A virus infection in Cyprus in four consecutive seasons (2009 pandemic-2013).Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice.Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance.Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistanceThe H275Y neuraminidase mutation of the pandemic A/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets.Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening.Epistatically interacting substitutions are enriched during adaptive protein evolutionRole of permissive neuraminidase mutations in influenza A/Brisbane/59/2007-like (H1N1) virusesBiophysics of protein evolution and evolutionary protein biophysicsEpistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza virusesUnderstanding the cross-resistance of oseltamivir to H1N1 and H5N1 influenza A neuraminidase mutations using multidimensional computational analyses.Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia.Impact of potential permissive neuraminidase mutations on viral fitness of the H275Y oseltamivir-resistant influenza A(H1N1)pdm09 virus in vitro, in mice and in ferrets.Detection and management of antiviral resistance for influenza viruses.Development and applications of single-cycle infectious influenza A virus (sciIAV).Epistasis in protein evolution.Susceptibility of influenza A(H1N1)/pdm2009, seasonal A(H3N2) and B viruses to Oseltamivir in Guangdong, China between 2009 and 2014.Characterization of oseltamivir-resistant influenza A(H1N1)pdm09 viruses in Taiwan in 2009-2011.The Ongoing Battle Against Influenza: Drug-resistant influenza viruses: why fitness matters
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P2860
A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A computational-experimental a ...... stant influenza neuraminidase.
@ast
A computational-experimental a ...... stant influenza neuraminidase.
@en
type
label
A computational-experimental a ...... stant influenza neuraminidase.
@ast
A computational-experimental a ...... stant influenza neuraminidase.
@en
prefLabel
A computational-experimental a ...... stant influenza neuraminidase.
@ast
A computational-experimental a ...... stant influenza neuraminidase.
@en
P2860
P1433
P1476
A computational-experimental a ...... stant influenza neuraminidase.
@en
P2093
David Baltimore
Jagannath S Nayak
P2860
P304
P356
10.1371/JOURNAL.PONE.0022201
P407
P577
2011-07-20T00:00:00Z