Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.
about
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)HIV-1 capsid: the multifaceted key player in HIV-1 infectionVirus strategies for passing the nuclear envelope barrierCPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 ReplicationDiscovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid ComplexesStructural basis for nuclear import of splicing factors by human Transportin 3Principles of Virus Uncoating: Cues and the Snooker BallGene expression analysis of a panel of cell lines that differentially restrict HIV-1 CA mutants infection in a cyclophilin a-dependent mannerSystems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's diseaseDifferential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integrationHIV-1 uncoating is facilitated by dynein and kinesin 1The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages.Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection.A retrovirus packages nascent host noncoding RNAs from a novel surveillance pathwayIn vivo biochemical analyses reveal distinct roles of β-importins and eEF1A in tRNA subcellular trafficInhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.TRIM5 and the Regulation of HIV-1 Infectivity.The Role of TNPO3 in HIV-1 Replication.A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore.Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein.A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.Single-cell imaging of HIV-1 provirus (SCIP).HIV-1 capsid is involved in post-nuclear entry stepsThe ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6.HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription.The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis.Viruses challenge selectivity barrier of nuclear poresViral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes.Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse modelCyclophilin A potentiates TRIM5α inhibition of HIV-1 nuclear import without promoting TRIM5α binding to the viral capsid.Nucleic Acid Binding by Mason-Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging.HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.N-terminal half of transportin SR2 interacts with HIV integrase.Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection.The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.
P2860
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P2860
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Transportin 3 promotes a nucle ...... r efficient HIV-1 integration.
@ast
Transportin 3 promotes a nucle ...... r efficient HIV-1 integration.
@en
type
label
Transportin 3 promotes a nucle ...... r efficient HIV-1 integration.
@ast
Transportin 3 promotes a nucle ...... r efficient HIV-1 integration.
@en
prefLabel
Transportin 3 promotes a nucle ...... r efficient HIV-1 integration.
@ast
Transportin 3 promotes a nucle ...... r efficient HIV-1 integration.
@en
P2860
P50
P1433
P1476
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration
@en
P2093
Elena Sokolskaja
Lihong Zhou
P2860
P304
P356
10.1371/JOURNAL.PPAT.1002194
P577
2011-08-25T00:00:00Z