Two site-directed mutations abrogate enzyme activity but have different effects on the conformation and cellular content of the N-acetylgalactosamine 4-sulphatase protein
about
Similar therapeutic efficacy between a single administration of gene therapy and multiple administrations of recombinant enzyme in a mouse model of lysosomal storage diseaseMucopolysaccharidosis type VI: Structural and clinical implications of mutations in N-acetylgalactosamine-4-sulfatase.Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patientsSulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.Mutations in ARSB in MPS VI patients in India.Low-dose Gene Therapy Reduces the Frequency of Enzyme Replacement Therapy in a Mouse Model of Lysosomal Storage Disease.Structural aspects of therapeutic enzymes to treat metabolic disorders.Heparan N-sulfatase: cysteine 70 plays a role in the enzyme catalysis and processing.Processing of normal lysosomal and mutant N-acetylgalactosamine 4-sulphatase: BiP (immunoglobulin heavy-chain binding protein) may interact with critical protein contact sites.Overexpression of inactive arylsulphatase mutants and in vitro activation by light-dependent oxidation with vanadate.Non-clinical Safety and Efficacy of an AAV2/8 Vector Administered Intravenously for Treatment of Mucopolysaccharidosis Type VI.Protein processing: a role in the pathophysiology of genetic disease.Specific hammerhead ribozymes reduce synthesis of cation-independent mannose 6-phosphate receptor mRNA and protein.
P2860
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P2860
Two site-directed mutations abrogate enzyme activity but have different effects on the conformation and cellular content of the N-acetylgalactosamine 4-sulphatase protein
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Two site-directed mutations ab ...... ctosamine 4-sulphatase protein
@ast
Two site-directed mutations ab ...... ctosamine 4-sulphatase protein
@en
type
label
Two site-directed mutations ab ...... ctosamine 4-sulphatase protein
@ast
Two site-directed mutations ab ...... ctosamine 4-sulphatase protein
@en
prefLabel
Two site-directed mutations ab ...... ctosamine 4-sulphatase protein
@ast
Two site-directed mutations ab ...... ctosamine 4-sulphatase protein
@en
P2093
P2860
P356
P1433
P1476
Two site-directed mutations ab ...... ctosamine 4-sulphatase protein
@en
P2093
C Bindloss
D A Robertson
J J Hopwood
P2860
P304
P356
10.1042/BJ3070457
P407
P478
307 ( Pt 2)
P577
1995-04-01T00:00:00Z