The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. - Wikidata - wikimedia - TriplyDB

The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.

The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.

http://www.wikidata.org/entity/Q30426930

about

Small G proteins in the cardiovascular system: physiological and pathological aspects Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-α2C-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent.5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.Actions of cAMP on calcium sensitization in human detrusor smooth muscle contraction.Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA.The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.β-blockers: a novel class of antitumor agents.Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway Phosphodiesterase 4 inhibition in the treatment of psoriasis, psoriatic arthritis and other chronic inflammatory diseases.The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle.Novel cAMP signalling paradigms: therapeutic implications for airway disease cAMP regulation of airway smooth muscle function.Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction.Rho-kinase: regulation, (dys)function, and inhibition.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.G-protein-mediated signaling in vascular smooth muscle cells - implications for vascular disease.β2 Agonists Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy.Calcium/calmodulin-dependent kinase 2 mediates Epac-induced spontaneous transient outward currents in rat vascular smooth muscle.The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP.Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries.Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery.Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume-expanded mice.MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.

P2860

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P2860

The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.

http://www.wikidata.org/entity/Q30426930

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

The cAMP-responsive Rap1 guani ...... n-regulation of RhoA activity.

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The cAMP-responsive Rap1 guani ...... n-regulation of RhoA activity.

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type

label

The cAMP-responsive Rap1 guani ...... n-regulation of RhoA activity.

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The cAMP-responsive Rap1 guani ...... n-regulation of RhoA activity.

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prefLabel

The cAMP-responsive Rap1 guani ...... n-regulation of RhoA activity.

@ast

The cAMP-responsive Rap1 guani ...... n-regulation of RhoA activity.

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JBC.M110.205062

P1433

Journal of Biological Chemistry

P1476

The cAMP-responsive Rap1 guani ...... n-regulation of RhoA activity.

@en

P2093

Aaron S Franke

http://www.w3.org/2001/XMLSchema#string

Alexander S Khromov

http://www.w3.org/2001/XMLSchema#string

Andra S Stevenson

http://www.w3.org/2001/XMLSchema#string

Avril V Somlyo

http://www.w3.org/2001/XMLSchema#string

Bartosz J Zieba

http://www.w3.org/2001/XMLSchema#string

Ko Momotani

http://www.w3.org/2001/XMLSchema#string

Li Jin

http://www.w3.org/2001/XMLSchema#string

Ruoya Ho

http://www.w3.org/2001/XMLSchema#string

P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha

Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration

Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A

Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels

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16681-16692

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scholarly article

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10.1074/JBC.M110.205062

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P433

19

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P478

286

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P50

Mykhaylo Artamonov

Magdalena Chrzanowska-Wodnicka

P577

2011-03-25T00:00:00Z

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50939774

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21454546

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P921

regulation of GTP binding

negative regulation of GTP binding

positive regulation of GTP binding

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3089510

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