Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.
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Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional ImplicationsSuperBiHelix method for predicting the pleiotropic ensemble of G-protein-coupled receptor conformations.Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptorComputational analysis of the CB1 carboxyl-terminus in the receptor-G protein complexAnandamide protects HT22 cells exposed to hydrogen peroxide by inhibiting CB1 receptor-mediated type 2 NADPH oxidase.Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 ReceptorLeveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.The predicted ensemble of low-energy conformations of human somatostatin receptor subtype 5 and the binding of antagonists.Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity
P2860
Q28551072-1A571D16-CB3A-40B2-8A27-F5E0E5125745Q30356936-312CB67E-51D5-4538-BFEC-ACCE264B1805Q30366048-E566872A-1A17-42EA-9744-C17CEC944521Q30385837-08788A6E-9C82-4501-AAAD-6E106E60EE3AQ34022370-D33202D8-5E4C-45BD-9304-3CEDFD51CFEFQ36890833-83633277-7E26-4493-940C-767D8F251272Q38973739-B7D8F1F8-A70A-4635-8275-28EA38191FE3Q41219614-014A9444-7909-46C6-9B84-712D7151CD72Q58798205-2BAFB7C5-637E-4422-82E3-782A52BA16C3
P2860
Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Computationally-predicted CB1 ...... stability, and ligand binding.
@ast
Computationally-predicted CB1 ...... stability, and ligand binding.
@en
type
label
Computationally-predicted CB1 ...... stability, and ligand binding.
@ast
Computationally-predicted CB1 ...... stability, and ligand binding.
@en
prefLabel
Computationally-predicted CB1 ...... stability, and ligand binding.
@ast
Computationally-predicted CB1 ...... stability, and ligand binding.
@en
P2093
P2860
P921
P356
P1433
P1476
Computationally-predicted CB1 ...... stability, and ligand binding.
@en
P2093
Caitlin E Scott
Debra A Kendall
Kwang H Ahn
William A Goddard
P2860
P304
P356
10.1002/PROT.24264
P407
P577
2013-06-14T00:00:00Z