The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.
about
Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor proteinCalcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.The genetics and neuropathology of Alzheimer's diseaseCALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastesGenome-wide association analysis of age-at-onset in Alzheimer's diseaseCALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neuronsCALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brainEffect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels.CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice.Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.Endoplasmic reticulum Ca(2+) handling in excitable cells in health and diseaseCALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.The NH2 terminus regulates voltage-dependent gating of CALHM ion channels.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseaseGenetic variability of the gene cluster CALHM 1-3 in sporadic Creutzfeldt-Jakob disease.Generation of Calhm1 knockout mouse and characterization of calhm1 gene expressionCLHM-1 is a functionally conserved and conditionally toxic Ca2+-permeable ion channel in Caenorhabditis elegansEpigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?Design of a comprehensive Alzheimer's disease clinic and research center in Spain to meet critical patient and family needs.Calcium homeostasis modulator (CALHM) ion channels.Alzheimer's disease: the challenge of the second century.How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel.CALHM1 and its polymorphism P86L differentially control Ca²⁺homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β.Genetic association of CALHM1 rs2986017 polymorphism with risk of Alzheimer's disease: a meta-analysis.CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells.Gas1 interferes with AβPP trafficking by facilitating the accumulation of immature AβPP in endoplasmic reticulum-associated raft subdomainsCalhm2 governs astrocytic ATP releasing in the development of depression-like behaviors.The APOE ɛ4 allele affects complexity and functional connectivity of resting brain activity in healthy adults.A 14 bp indel variation in the NCX1 gene modulates the age at onset in late-onset Alzheimer's disease.Blockade and knock-out of CALHM1 channels attenuate ischemic brain damage.ATP Release Channels.
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P2860
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.
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2010 nî lūn-bûn
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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2010 թվականի հունվարին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
The CALHM1 P86L polymorphism i ...... isease: a meta-analysis study.
@ast
The CALHM1 P86L polymorphism i ...... isease: a meta-analysis study.
@en
type
label
The CALHM1 P86L polymorphism i ...... isease: a meta-analysis study.
@ast
The CALHM1 P86L polymorphism i ...... isease: a meta-analysis study.
@en
prefLabel
The CALHM1 P86L polymorphism i ...... isease: a meta-analysis study.
@ast
The CALHM1 P86L polymorphism i ...... isease: a meta-analysis study.
@en
P2093
P2860
P50
P356
P1476
The CALHM1 P86L polymorphism i ...... isease: a meta-analysis study.
@en
P2093
Agustin Ruiz
Alberto Pilotto
Ana Frank-Garcia
Annick Alpérovitch
Antonio González-Pérez
Brit-Maren Michaud Schjeide
Carmen Antunez
David Mann
Davide Seripa
Elicer Coto
P2860
P304
P356
10.3233/JAD-2010-100933
P50
P577
2010-01-01T00:00:00Z