Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells - Wikidata - wikimedia - TriplyDB

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells

http://www.wikidata.org/entity/Q30435060

about

Regulation of the ovarian reserve by members of the transforming growth factor beta family Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development.Selective Smad4 knockout in ovarian preovulatory follicles results in multiple defects in ovulation Minireview: physiological and pathological actions of RAS in the ovary.TOP2β is essential for ovarian follicles that are hypersensitive to chemotherapeutic drugs The ovary: basic biology and clinical implications Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.MUC1 positive, Kras and Pten driven mouse gynecologic tumors replicate human tumors and vary in survival and nuclear grade based on anatomical location.Persistent ERK/MAPK activation promotes lactotrope differentiation and diminishes tumorigenic phenotype.Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis.High-grade serous ovarian cancer arises from fallopian tube in a mouse model.Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival.Minireview: animal models and mechanisms of ovarian cancer development.Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly.New insights into ovarian function.Tumorigenesis and peritoneal colonization from fallopian tube epithelium.Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum.Technical challenges and limitations of current mouse models of ovarian cancer.PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.Mutant p53 Promotes Epithelial Ovarian Cancer by Regulating Tumor Differentiation, Metastasis, and Responsiveness to Steroid Hormones.Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.The mammalian ovary from genesis to revelation.Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis Tumor repressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases.Immunobiology of human mucin 1 in a preclinical ovarian tumor model.Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.Advances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis.Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse.Salivary miR-16, miR-191 and miR-223: intuitive indicators of dominant ovarian follicles in buffaloes.Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice.A mouse model for endometrioid ovarian cancer arising from the distal oviduct.The Endometriotic Tumor Microenvironment in Ovarian Cancer

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P2860

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells

http://www.wikidata.org/entity/Q30435060

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Cell type-specific targeted mu ...... arian surface epithelial cells

@ast

Cell type-specific targeted mu ...... arian surface epithelial cells

@en

type

label

Cell type-specific targeted mu ...... arian surface epithelial cells

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Cell type-specific targeted mu ...... arian surface epithelial cells

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prefLabel

Cell type-specific targeted mu ...... arian surface epithelial cells

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Cell type-specific targeted mu ...... arian surface epithelial cells

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0008-5472.CAN-08-3363

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Cancer Research

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Cell type-specific targeted mu ...... arian surface epithelial cells

@en

P2093

Heng-Yu Fan

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Jinrong Wang

http://www.w3.org/2001/XMLSchema#string

JoAnne S Richards

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John P Lydon

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Marilene Paquet

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Zhilin Liu

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P2860

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Animal models of ovarian cancer

The biology and clinical relevance of the PTEN tumor suppressor pathway

Requirement of Bmpr1a for Müllerian duct regression during male sexual development

Essential role of Plzf in maintenance of spermatogonial stem cells

Pten is essential for embryonic development and tumour suppression

Plzf is required in adult male germ cells for stem cell self-renewal

MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

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6463-6472

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16

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69

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Francesco J DeMayo

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19679546

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