The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
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Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic ratsFundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's diseaseeIF5A isoforms and cancer: two brothers for two functions?Islet inflammation: a unifying target for diabetes treatment?Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathyA novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformationDeoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetesIslet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model.Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes developmentInhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetesClock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function.Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice.Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulationHuman adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors.Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activationImpact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteome12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway.Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue.Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response.Eukaryotic initiation factor 5A plays an essential role in luteinizing hormone receptor regulationMinireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancerDeoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.Hyperuricemia causes pancreatic β-cell death and dysfunction through NF-κB signaling pathway.Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.SNS01-T modulation of eIF5A inhibits B-cell cancer progression and synergizes with bortezomib and lenalidomide.Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.Biological Relevance and Therapeutic Potential of the Hypusine Modification System.Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing ProteinsPolyamine biosynthesis is critical for growth and differentiation of the pancreas.Preliminary Proteomic Analysis of A549 Cells Infected with Avian Influenza Virus H7N9 and Influenza A Virus H1N1Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.Modulation of eIF5A expression using SNS01 nanoparticles inhibits NF-κB activity and tumor growth in murine models of multiple myeloma.Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cellsMitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death.Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells
P2860
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P2860
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The unique hypusine modificati ...... ation and dysfunction in mice.
@ast
The unique hypusine modificati ...... ation and dysfunction in mice.
@en
type
label
The unique hypusine modificati ...... ation and dysfunction in mice.
@ast
The unique hypusine modificati ...... ation and dysfunction in mice.
@en
prefLabel
The unique hypusine modificati ...... ation and dysfunction in mice.
@ast
The unique hypusine modificati ...... ation and dysfunction in mice.
@en
P2093
P2860
P50
P356
P1476
The unique hypusine modificati ...... ation and dysfunction in mice.
@en
P2093
Anthony P Trace
Bernhard Maier
Catherine A Taylor
Eli C Lewis
Jerry L Nadler
John E Thompson
Natalie D Stull
Reiesha D Robbins
Richard S Dondero
Swarup K Chakrabarti
P2860
P304
P356
10.1172/JCI38924
P407
P577
2010-05-24T00:00:00Z