Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b.

Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b.

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http://www.wikidata.org/entity/Q30441028

Q30441028

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A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells.Targeting Src family kinases in anti-cancer therapies: turning promise into triumph Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton.NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance Oncoproteomic analysis reveals co-upregulation of RELA and STAT5 in carboplatin resistant ovarian carcinoma P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation Dynamics and mechanism of p130Cas localization to focal adhesions Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression.BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways.A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration.Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.Pathways to tamoxifen resistance.SRChing for the substrates of Src.Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.Motif-guided sparse decomposition of gene expression data for regulatory module identification.Identifying cancer biomarkers by network-constrained support vector machines.A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer.Prolactin induces up-regulation of its cognate receptor in breast cancer cells via transcriptional activation of its generic promoter by cross-talk between ERα and STAT5 Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.Src Is a Potential Therapeutic Target in Endocrine-Resistant Breast Cancer Exhibiting Low Estrogen Receptor-Mediated Transactivation.Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic A phase I study of dasatinib and weekly paclitaxel for metastatic breast cancer The Src signaling pathway: a potential target in melanoma and other malignancies.Sensitization of estrogen receptor-positive breast cancer cell lines to 4-hydroxytamoxifen by isothiocyanates present in cruciferous plants.The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells.Calmodulin modulates Akt activity in human breast cancer cell lines.STAT signaling in different breast cancer sub-types.ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer.Estrogen Regulation of MicroRNA Expression Targeting important pathways in head and neck cancer: from the bench to the clinic.Prolactin activates ERα in the absence of ligand in female mammary development and carcinogenesis in vivo Expression of a phosphorylated p130(Cas) substrate domain attenuates the phosphatidylinositol 3-kinase/Akt survival pathway in tamoxifen resistant breast cancer cells.A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.Preanalytical investigations of phlebotomy: methodological aspects, pitfalls and recommendations.Targeting the subtypes of breast cancer: rethinking investigational drugs.Cellular functions regulated by phosphorylation of EGFR on Tyr845.

P2860

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P2860

Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b.

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http://www.wikidata.org/entity/Q30441028

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