Haploinsufficiency at the protein kinase A RI alpha gene locus leads to fertility defects in male mice and men
about
Significant expression levels of transgenic PPP1CC2 in testis and sperm are required to overcome the male infertility phenotype of Ppp1cc null miceCell-type specific expression of a dominant negative PKA mutation in mice.Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility.Disruption of estrogen receptor signaling and similar pathways in the efferent ductules and initial segment of the epididymisThe genetic basis and fitness consequences of sperm midpiece size in deer mice.Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertilityPKA, germ cells, and fertility.Mendelian genetics of male infertilityCell-type-specific isolation of ribosome-associated mRNA from complex tissues.The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.Selective expression of a dominant-negative type Iα PKA regulatory subunit in striatal medium spiny neurons impairs gene expression and leads to reduced feeding and locomotor activity.The 'omics revolution and our understanding of sperm cell biology.Sperm-specific AKAP3 is a dual-specificity anchoring protein that interacts with both protein kinase a regulatory subunits via conserved N-terminal amphipathic peptides.AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis.The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit
P2860
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P2860
Haploinsufficiency at the protein kinase A RI alpha gene locus leads to fertility defects in male mice and men
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
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2006年論文
@zh-tw
2006年论文
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name
Haploinsufficiency at the prot ...... y defects in male mice and men
@ast
Haploinsufficiency at the prot ...... y defects in male mice and men
@en
type
label
Haploinsufficiency at the prot ...... y defects in male mice and men
@ast
Haploinsufficiency at the prot ...... y defects in male mice and men
@en
prefLabel
Haploinsufficiency at the prot ...... y defects in male mice and men
@ast
Haploinsufficiency at the prot ...... y defects in male mice and men
@en
P2093
P2860
P356
P1476
Haploinsufficiency at the prot ...... y defects in male mice and men
@en
P2093
Craig T Basson
David Wilkes
Deborah A McDermott
G Stanley McKnight
Kimberly A Burton
Marc Goldstein
Melissa N Poulsen
P2860
P304
P356
10.1210/ME.2006-0060
P577
2006-05-25T00:00:00Z