Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. - Wikidata - wikimedia - TriplyDB

Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.

Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.

http://www.wikidata.org/entity/Q30445842

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Genetics and neuropathology of Huntington's disease Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis.Genome scan in familial late-onset Alzheimer's disease: a locus on chromosome 6 contributes to age-at-onset Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs Identifying modifier genes of monogenic disease: strategies and difficulties.Genetic analysis of polymorphisms in the kalirin gene for association with age-at-onset in European Huntington disease patients.Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients.Chromosome substitution strain assessment of a Huntington's disease modifier locus Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease.The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease.Abnormal Weight and Body Mass Index in Children with Juvenile Huntington's Disease.Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.A brief history of triplet repeat diseases.β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease.Molecular mechanisms and potential therapeutical targets in Huntington's disease.The clinical and genetic features of Huntington disease.Mitochondrial and metabolic-based protective strategies in Huntington's disease: the case of creatine and coenzyme Q.Choosing and using Drosophila models to characterize modifiers of Huntington's disease.DNA repair mechanisms in Huntington's disease.Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors.Genetic modifiers of Huntington's disease.The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.Huntington's Disease: Relationship Between Phenotype and Genotype.Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats.Huntington's disease: the case for genetic modifiers.Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease.PGC-1alpha as modifier of onset age in Huntington disease.Juvenile Huntington disease exacerbated by methylphenidate: case report.Huntington Disease: Molecular Diagnostics Approach.The number of CAG repeats within the normal allele does not influence the age of onset in Huntington's disease.Genetics Modulate Gray Matter Variation Beyond Disease Burden in Prodromal Huntington's Disease.Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG).

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Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.

http://www.wikidata.org/entity/Q30445842

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2006 nî lūn-bûn

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2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2006 թվականի օգոստոսին հրատարակված գիտական հոդված

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Adam Rosenblatt

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Alice Lazzarini

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Andrea Zanko

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Anthony J Lechich

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Ayana Duckett

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Carmen Ayuso García

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Jang-Ho J Cha

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P2860

Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants

Huntington disease: genetics and epidemiology

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

Merlin--rapid analysis of dense genetic maps using sparse gene flow trees

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Huntingtin interacts with a family of WW domain proteins

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

Multipoint quantitative-trait linkage analysis in general pedigrees

Comprehensive human genetic maps: individual and sex-specific variation in recombination

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James F. Gusella

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Jane S. Paulsen

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Marcy E. MacDonald

Michael R. Hayden

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1042500897

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16914060

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Huntington disease

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1586197

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