Tumorigenicity of adenovirus-transformed rodent cells is influenced by at least two regions of adenovirus type 12 early region 1A.
about
Early region 1 transforming functions are dispensable for mammary tumorigenesis by human adenovirus type 9.The N terminus of adenovirus type 12 E1A inhibits major histocompatibility complex class I expression by preventing phosphorylation of NF-kappaB p65 Ser276 through direct binding.In adenovirus type 12 tumorigenic cells, major histocompatibility complex class I transcription shutoff is overcome by induction of NF-kappaB and relief of COUP-TFII repression.Investigation of adenovirus occurrence in pediatric tumor entities.Transformation by E1A oncoprotein involves ubiquitin-mediated proteolysis of the neuronal and tumor repressor REST in the nucleus.Constructing chimeric type 12/type 5 adenovirus E1A genes and using them to identify an oncogenic determinant of adenovirus type 12.Reduced phosphorylation of p50 is responsible for diminished NF-kappaB binding to the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells.Comparative sequence analysis of the largest E1A proteins of human and simian adenoviruses.E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter.
P2860
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P2860
Tumorigenicity of adenovirus-transformed rodent cells is influenced by at least two regions of adenovirus type 12 early region 1A.
description
1994 nî lūn-bûn
@nan
1994 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Tumorigenicity of adenovirus-t ...... virus type 12 early region 1A.
@ast
Tumorigenicity of adenovirus-t ...... virus type 12 early region 1A.
@en
type
label
Tumorigenicity of adenovirus-t ...... virus type 12 early region 1A.
@ast
Tumorigenicity of adenovirus-t ...... virus type 12 early region 1A.
@en
prefLabel
Tumorigenicity of adenovirus-t ...... virus type 12 early region 1A.
@ast
Tumorigenicity of adenovirus-t ...... virus type 12 early region 1A.
@en
P2093
P2860
P1433
P1476
Tumorigenicity of adenovirus-t ...... virus type 12 early region 1A.
@en
P2093
P2860
P304
P577
1994-02-01T00:00:00Z