Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.
about
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of SrcHuman immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityActivation of murine c-abl protooncogene: effect of a point mutation on oncogenic activationAssociation of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activityEps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signalsA single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef proteinIdentification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domainsMutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinaseTwo species of human CRK cDNA encode proteins with distinct biological activitiesEssential motions and energetic contributions of individual residues in a peptide bound to an SH3 domain.LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck.3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts.Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA)Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylationBoth the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src.Identification and characterization of a novel cytoskeleton-associated pp60src substrate.Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitorThe SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells.Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteinsSrc regulated by C-terminal phosphorylation is monomericTubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranesSignal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigenIdentification of a novel neuronal C-SRC exon expressed in human brain.Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.Structural differences between repressed and derepressed forms of p60c-srcBiological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts.Activation of protein serine/threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: signal transduction/transformation-dependent MBP kinases.Transformation of chicken embryo fibroblast cells by avian retroviruses containing the human Fyn gene and its mutated genes.
P2860
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P2860
Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.
description
1988 nî lūn-bûn
@nan
1988 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Activation of pp60c-src transf ...... ain containing residues 90-95.
@ast
Activation of pp60c-src transf ...... ain containing residues 90-95.
@en
type
label
Activation of pp60c-src transf ...... ain containing residues 90-95.
@ast
Activation of pp60c-src transf ...... ain containing residues 90-95.
@en
prefLabel
Activation of pp60c-src transf ...... ain containing residues 90-95.
@ast
Activation of pp60c-src transf ...... ain containing residues 90-95.
@en
P2093
P1433
P1476
Activation of pp60c-src transf ...... ain containing residues 90-95.
@en
P2093
Lansing TJ
Parsons JT
Reynolds AB
P304
P577
1988-01-01T00:00:00Z