Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice - Wikidata - wikimedia - TriplyDB

Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice

Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice

http://www.wikidata.org/entity/Q30461096

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Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Behavioral phenotypes of genetic mouse models of autism.Modeling psychiatric disorders for developing effective treatments The molecular basis of cognitive deficits in pervasive developmental disorders Therapeutic approaches for shankopathies Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) mice Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Neural selectivity for communicative auditory signals in Phelan-McDermid syndrome.Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies Neurobiology of social behavior abnormalities in autism and Williams syndrome Discovery of Rare Mutations in Autism: Elucidating Neurodevelopmental Mechanisms Phelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoring Adult restoration of Shank3 expression rescues selective autistic-like phenotypes Letting a typical mouse judge whether mouse social interactions are atypical AMPAKINE enhancement of social interaction in the BTBR mouse model of autism Effect of social odor context on the emission of isolation-induced ultrasonic vocalizations in the BTBR T+tf/J mouse model for autism.GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.Found in translation: Understanding the biology and behavior of experimental traumatic brain injury Social communication in mice--are there optimal cage conditions?Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.SHANK proteins: roles at the synapse and in autism spectrum disorder.Expression of SHANK3 in the Temporal Neocortex of Patients with Intractable Temporal Epilepsy and Epilepsy Rat Models.CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency.Ultrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice.Molecular handoffs in nitrergic neurotransmission Synaptic proteins and receptors defects in autism spectrum disorders Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations.16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions.

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P2860

Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice

http://www.wikidata.org/entity/Q30461096

description

2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Reduced excitatory neurotransm ...... escent Shank3 null mutant mice

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Reduced excitatory neurotransm ...... escent Shank3 null mutant mice

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type

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Reduced excitatory neurotransm ...... escent Shank3 null mutant mice

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Reduced excitatory neurotransm ...... escent Shank3 null mutant mice

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Reduced excitatory neurotransm ...... escent Shank3 null mutant mice

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Reduced excitatory neurotransm ...... escent Shank3 null mutant mice

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JNEUROSCI.6107-11.2012

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Journal of Neuroscience

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Reduced excitatory neurotransm ...... escent Shank3 null mutant mice

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Adam M Katz

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Danielle N Abrams

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David Kalikhman

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Florence I Roullet

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Harrison Simon

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Jacqueline N Crawley

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Jill L Silverman

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Leuk Woldeyohannes

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Markus Wöhr

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P2860

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

Deletion 22q13.3 syndrome

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

Multiple rare variants in the etiology of autism spectrum disorders

Contribution of SHANK3 mutations to autism spectrum disorder

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6525-6541

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Joseph D. Buxbaum

Maria Luisa Scattoni

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