The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
about
Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitroPositive and negative regulation of endogenous genes by designed transcription factorsRole of helical constraints of the EBS1-IBS1 duplex of a group II intron on demarcation of the 5' splice siteThe Cbp2 protein stimulates the splicing of the omega intron of yeast mitochondria.Crystal structure of a phage Twort group I ribozyme-product complexCharacterization of the spermidine-dependent, sequence-specific endoribonuclease that requires transfer RNA for its activityEffects of substrate structure on the kinetics of circle opening reactions of the self-splicing intervening sequence from Tetrahymena thermophila: evidence for substrate and Mg2+ binding interactionsThe self-cleaving domain from the genomic RNA of hepatitis delta virus: sequence requirements and the effects of denaturant.Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis.A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification.Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core.Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme.The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing.Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopyMinor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site.Two major tertiary folding transitions of the Tetrahymena catalytic RNA.Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymesCUUCGG hairpins: extraordinarily stable RNA secondary structures associated with various biochemical processes.Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.Stereoselective arginine binding is a phylogenetically conserved property of group I self-splicing RNAs.The role of the toxicologic pathologist in the preclinical safety evaluation of biotechnology-derived pharmaceuticals.Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro.Intracellular RNA cleavage by the hairpin ribozyme.Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the moleculeNonspecific binding to structured RNA and preferential unwinding of an exposed helix by the CYT-19 protein, a DEAD-box RNA chaperone.Ribozyme therapy: RNA enzymes to the rescue.A modular, bifunctional RNA that integrates itself into a target RNA.A novel technique for the rapid preparation of mutant RNAsCatalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5.Two guanosine binding sites exist in group I self-splicing IVS RNAs.Reactivity of modified ribose moieties of guanosine: new cleavage reactions mediated by the IVS of Tetrahymena precursor rRNA.An alternative helix in the 26S rRNA promotes excision and integration of the Tetrahymena intervening sequence.Transcription in vitro of Tetrahymena class II and class III genes.Combinatorial libraries by cassette mutagenesis.Efficient site-specific cleavage by RNase MRP requires interaction with two evolutionarily conserved mitochondrial RNA sequencesBase pairing between the 3' exon and an internal guide sequence increases 3' splice site specificity in the Tetrahymena self-splicing rRNA intron.Ribozyme-mediated high resistance against potato spindle tuber viroid in transgenic potatoes.Site-specific cleavage of the transactivation response site of human immunodeficiency virus RNA with a tat-based chemical nucleaseA self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+).
P2860
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P2860
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
description
1986 nî lūn-bûn
@nan
1986 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
@ast
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
@en
type
label
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
@ast
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
@en
prefLabel
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
@ast
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
@en
P2093
P356
P1433
P1476
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
@en
P2093
P2888
P304
P356
10.1038/324429A0
P407
P577
1986-12-01T00:00:00Z
P6179
1051728875