Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism.
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Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymesLigand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells.Glycogen synthase kinase 3beta and extracellular signal-regulated kinase inactivate heat shock transcription factor 1 by facilitating the disappearance of transcriptionally active granules after heat shockSphingosine 1-phosphate signalling in mammalian cells.Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.Autophagy in the light of sphingolipid metabolismIsoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK.A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes.Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survivalEffect of sphingosine kinase 1 inhibition on blood pressure.High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function.Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapySphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation.Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cellsSphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells.Molecular diversity of sphingolipid signalling.12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells.Synergism among lysophosphatidic acid, beta1A integrins, and epidermal growth factor or platelet-derived growth factor in mediation of cell migration.Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinaseSphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptorSphingosine inhibits voltage-operated calcium channels in GH4C1 cells.Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism.Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells.Regulation of cytochromes P450 during inflammation and infection.The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways.Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine.Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells.Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1.Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades.Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism.Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts.ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphateActivation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis.
P2860
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P2860
Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism.
description
1995 nî lūn-bûn
@nan
1995 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Sphingosine 1-phosphate rapidl ...... G protein-dependent mechanism.
@ast
Sphingosine 1-phosphate rapidl ...... G protein-dependent mechanism.
@en
type
label
Sphingosine 1-phosphate rapidl ...... G protein-dependent mechanism.
@ast
Sphingosine 1-phosphate rapidl ...... G protein-dependent mechanism.
@en
prefLabel
Sphingosine 1-phosphate rapidl ...... G protein-dependent mechanism.
@ast
Sphingosine 1-phosphate rapidl ...... G protein-dependent mechanism.
@en
P2093
P356
P1476
Sphingosine 1-phosphate rapidl ...... G protein-dependent mechanism.
@en
P2093
P304
11484-11488
P356
10.1074/JBC.270.19.11484
P407
P577
1995-05-01T00:00:00Z