Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
about
On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic interventionSuppression of the Arboviruses Dengue and Chikungunya Using a Dual-Acting Group-I Intron Coupled with Conditional Expression of the Bax C-Terminal DomainGroup I aptazymes as genetic regulatory switches.Three subsets of sequence complexity and their relevance to biopolymeric information.Prospects for nucleic acid-based therapeutics against hepatitis C virusEmerging clinical applications of RNAUse of a Fluorescent Aptamer RNA as an Exonic Sequence to Analyze Self-Splicing Ability of aGroup I Intron from Structured RNAsIn vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron.Group I introns: new molecular mechanisms for mRNA repair.Protein-dependent ribozymes report molecular interactions in real time.Optimization of trans-splicing ribozyme efficiency and specificity by in vivo genetic selection.Ribozymes: the characteristics and properties of catalytic RNAs.Targeting of highly conserved Dengue virus sequences with anti-Dengue virus trans-splicing group I introns.Effective suppression of dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domainEvaluating group I intron catalytic efficiency in mammalian cells.Toward the therapeutic editing of mutated RNA sequences.Evaluating target silencing by short hairpin RNA mediated by the group I intron in cultured mammalian cellsTherapeutic potential of ribozymes in haematological disorders.Gene therapy and retinitis pigmentosa: advances and future challenges.An in vivo selection method to optimize trans-splicing ribozymesRibozymes in gene therapy.Intracellular ribozyme-catalyzed trans-cleavage of RNA monitored by fluorescence resonance energy transfer.Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes.RNA-directed construction of structurally complex and active ligase ribozymes through recombinationFusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro.Design and Experimental Evolution of trans-Splicing Group I Intron Ribozymes.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsRibozyme-mediated revision of RNA and DNAMessenger RNA reprogramming by spliceosome-mediated RNA trans-splicingSpliceozymes: ribozymes that remove introns from pre-mRNAs in trans.Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse modelEngineered ribozymes as molecular tools for site-specific alteration of RNA sequence.Computational prediction of efficient splice sites for trans-splicing ribozymes.Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA RegulationPotential therapy paradigms for Marfan syndrome.Design of highly specific cytotoxins by using trans-splicing ribozymes.Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.AAV vectors for RNA-based modulation of gene expression.Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible?Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts.
P2860
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P2860
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
@ast
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
@en
type
label
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
@ast
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
@en
prefLabel
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
@ast
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
@en
P356
P1433
P1476
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
@en
P2093
P2888
P304
P356
10.1038/371619A0
P407
P577
1994-10-01T00:00:00Z
P6179
1027762521