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Two modes of lytic granule fusion during degranulation by natural killer cells

Two modes of lytic granule fusion during degranulation by natural killer cells

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LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity Cell biological steps and checkpoints in accessing NK cell cytotoxicity Cell polarisation and the immunological synapse Illumination of the spatial order of intracellular pH by genetically encoded pH-sensitive sensors Transmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis.Vesicle Motion during Sustained Exocytosis in Chromaffin Cells: Numerical Model Based on Amperometric Measurements.Human NK cell lytic granules and regulation of their exocytosis Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells.ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56 dim CD16+ and CD56 bright CD16 dim/- natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes.In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology.Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.Cd226-/- natural killer cells fail to establish stable contacts with cancer cells and show impaired control of tumor metastasis in vivo.A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.Cholesterol-dependent cytolysins impair pro-inflammatory macrophage responses.Single Degranulations in NK Cells Can Mediate Target Cell Killing.Human NK Cells Develop an Exhaustion Phenotype During Polar Degranulation at the Hyphal Synapse

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P2860

Two modes of lytic granule fusion during degranulation by natural killer cells

http://www.wikidata.org/entity/Q30471500

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Two modes of lytic granule fusion during degranulation by natural killer cells

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Two modes of lytic granule fusion during degranulation by natural killer cells

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type

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Two modes of lytic granule fusion during degranulation by natural killer cells

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Two modes of lytic granule fusion during degranulation by natural killer cells

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Two modes of lytic granule fusion during degranulation by natural killer cells

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Two modes of lytic granule fusion during degranulation by natural killer cells

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Immunology & Cell Biology

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Two modes of lytic granule fusion during degranulation by natural killer cells

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Dongfang Liu

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Eric O Long

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John A Hammer

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Jose A Martina

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Xufeng S Wu

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P2860

Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

The synaptic vesicle cycle

Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

Membrane fusion: grappling with SNARE and SM proteins

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

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728-738

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scholarly article

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10.1038/ICB.2010.167

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6

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89

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2011-04-12T00:00:00Z

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51042210

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21483445

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3257049

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