Progress in corticotropin-releasing factor-1 antagonist development. - Wikidata - wikimedia - TriplyDB

Progress in corticotropin-releasing factor-1 antagonist development.

Progress in corticotropin-releasing factor-1 antagonist development.

http://www.wikidata.org/entity/Q30475627

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Structure of class B GPCR corticotropin-releasing factor receptor 1 Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation Corticotrophin-releasing factor 1 activation in the central amygdale and visceral hyperalgesia Role of kappa-opioid receptors in stress and anxiety-related behavior.Drug withdrawal conceptualized as a stressor.Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism.Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus Don't stress about CRF: assessing the translational failures of CRF1antagonists.Forebrain-specific CRF overproduction during development is sufficient to induce enduring anxiety and startle abnormalities in adult mice The role of PKC signaling in CRF-induced modulation of startle.Alcohol stress response dampening during imminent versus distal, uncertain threat.Corticotropin-releasing factor (CRF)-induced disruption of attention in rats is blocked by the κ-opioid receptor antagonist JDTic.Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors.Stress and visceral pain: from animal models to clinical therapies Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view.Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention.Corticotropin releasing factor receptor antagonists for major depressive disorder.Role of bed nucleus of the stria terminalis corticotrophin-releasing factor receptors in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction.Stress controversies: post-traumatic stress disorder, hippocampal volume, gastroduodenal ulceration*.Corticotropin releasing factor: a key role in the neurobiology of addiction Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity.Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia.The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats.Structures of class B G protein-coupled receptors: prospects for drug discovery.Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.Corticotropin-releasing factor signaling and visceral response to stress.Translational and reverse translational research on the role of stress in drug craving and relapse.Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1β administration.Advances in the Management of Treatment-Resistant Depression Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.The neurobiological correlates of childhood adversity and implications for treatment.Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.Addiction and brain reward and antireward pathways.Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity.Corticotrophin releasing factor accelerates neuropathology and cognitive decline in a mouse model of Alzheimer's disease.Alcohol in excess: CRF₁ receptors in the rat and mouse VTA and DRN.Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation.Molecular Neurobiology and Promising New Treatment in Depression.

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Progress in corticotropin-releasing factor-1 antagonist development.

http://www.wikidata.org/entity/Q30475627

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2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Progress in corticotropin-releasing factor-1 antagonist development.

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Progress in corticotropin-releasing factor-1 antagonist development.

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Progress in corticotropin-releasing factor-1 antagonist development.

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Progress in corticotropin-releasing factor-1 antagonist development.

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J.DRUDIS.2010.02.011

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Drug Discovery Today

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Progress in corticotropin-releasing factor-1 antagonist development.

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Eric P Zorrilla

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George F Koob

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P2860

CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

Stress, dysregulation of drug reward pathways, and the transition to drug dependence

A role for brain stress systems in addiction.

NMR structural characterization of a minimal peptide antagonist bound to the extracellular domain of the corticotropin-releasing factor1 receptor

Common and divergent structural features of a series of corticotropin releasing factor-related peptides

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist

Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists

The reinstatement model of drug relapse: history, methodology and major findings

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371-383

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10.1016/J.DRUDIS.2010.02.011

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20206287

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