Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol
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Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and CarvedilolGraphical approach to model reduction for nonlinear biochemical networks.Modeling the effects of β1-adrenergic receptor blockers and polymorphisms on cardiac myocyte Ca2+ handling.Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cellsGPCR and G proteins: drug efficacy and activation in live cells.Beta-blocker pharmacogenetics in heart failure.Teaching old receptors new tricks: biasing seven-transmembrane receptors.Functional selectivity in adrenergic and angiotensin signaling systems.Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonismBeta 1- and beta 2-adrenoceptor polymorphisms and cardiovascular diseases.Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variantGenetically encodable fluorescent biosensors for tracking signaling dynamics in living cells.Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individualsThe genomic architecture of sporadic heart failureThe atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors.Theme and variations on kinetics of GPCR activation/deactivation.Recording kinetics of adrenergic receptor activation in live cells.Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptorCompartmentalization of beta-adrenergic signals in cardiomyocytes.Studying ligand efficacy at G protein-coupled receptors using FRET.Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) studyDifferential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programsBeta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization.Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open.Role of beta adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis.Kinetics of G-protein-coupled receptor signals in intact cellsBeta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases.Fluorescence changes reveal kinetic steps of muscarinic receptor-mediated modulation of phosphoinositides and Kv7.2/7.3 K+ channels.Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization.Designing heart performance by gene transfer.Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failurePharmacogenetics in heart failure: promises and challenges.Illuminating the life of GPCRsPharmacogenetic profiling in the treatment of heart disease.Adrenergic signaling polymorphisms and their impact on cardiovascular disease.Exploration of biarsenical chemistry--challenges in protein research.Clinical considerations of heritable factors in common heart failure
P2860
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P2860
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Real-time optical recording of ...... e Arg389 variant to carvedilol
@ast
Real-time optical recording of ...... e Arg389 variant to carvedilol
@en
type
label
Real-time optical recording of ...... e Arg389 variant to carvedilol
@ast
Real-time optical recording of ...... e Arg389 variant to carvedilol
@en
prefLabel
Real-time optical recording of ...... e Arg389 variant to carvedilol
@ast
Real-time optical recording of ...... e Arg389 variant to carvedilol
@en
P2860
P50
P356
P1476
Real-time optical recording of ...... e Arg389 variant to carvedilol
@en
P2093
Moritz Bünemann
Viacheslav O Nikolaev
P2860
P304
P356
10.1172/JCI30012
P407
P577
2007-01-01T00:00:00Z