Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.

Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.

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http://www.wikidata.org/entity/Q30479062
Molecular targets for selective killing of TRAIL-resistant leukemic cells.Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells.Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosisReal-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors.Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development.Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells.Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism.Identification of Mitoxantrone as a TRAIL-sensitizing agent for Glioblastoma MultiformeImplementation and Challenges of Direct Acoustic Dosing into Cell-Based Assays.Novel indazole-based small compounds enhance TRAIL-induced apoptosis by inhibiting the MKK7-TIPRL interaction in hepatocellular carcinoma.
P2860

Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.

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http://www.wikidata.org/entity/Q30479062
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2010 nî lūn-bûn
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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Novel HTS strategy identifies ...... the caspase-8 apoptotic axis.
@ast
Novel HTS strategy identifies ...... the caspase-8 apoptotic axis.
@en
type
label
Novel HTS strategy identifies ...... the caspase-8 apoptotic axis.
@ast
Novel HTS strategy identifies ...... the caspase-8 apoptotic axis.
@en
prefLabel
Novel HTS strategy identifies ...... the caspase-8 apoptotic axis.
@ast
Novel HTS strategy identifies ...... the caspase-8 apoptotic axis.
@en
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Novel HTS strategy identifies ...... the caspase-8 apoptotic axis.
@en
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P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0013375
P407
P433
P478
P577
P5875
P698
P921
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