Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42 - Wikidata - wikimedia - TriplyDB

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42

http://www.wikidata.org/entity/Q30479901

about

Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients Quantification of HER family receptors in breast cancer Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells Open conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scattering Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.Conformational switching in ezrin regulates morphological and cytoskeletal changes required for B cell chemotaxis The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity.An integrative approach to the identification of Arabidopsis and rice genes involved in xylan and secondary wall development.17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2 Kinase-mediated quasi-dimers of EGFR MMP-9 and CXCL8/IL-8 are potential therapeutic targets in epidermolysis bullosa simplex.Emerging role for ERM proteins in cell adhesion and migration.ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion Molecular and functional imaging of invasion and metastasis: windows into the metastatic cascade.The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion.Fluorescence lifetime endoscopy using TCSPC for the measurement of FRET in live cells.Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway Integrin regulation of caveolin function.PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.Interactome analysis reveals ezrin can adopt multiple conformational states.How Förster resonance energy transfer imaging improves the understanding of protein interaction networks in cancer biology.Re-defining ERM function in lymphocyte activation and migration.Function of ezrin-radixin-moesin proteins in migration of subventricular zone-derived neuroblasts following traumatic brain injury.Novel mechanism of JNK pathway activation by adenoviral E1A.Quantitative analysis of ezrin turnover dynamics in the actin cortex.Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation.A link between two tumorigenic proteins, CD44 and p21WAF1: CD44 increases phorbol ester-induced expression of p21WAF1 by stabilizing its mRNA and extending protein half-life.P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

P2860

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P2860

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42

http://www.wikidata.org/entity/Q30479901

description

2007 nî lūn-bûn

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2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2007 թվականի մայիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Activated ezrin promotes cell ...... downstream activation of Cdc42

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Activated ezrin promotes cell ...... downstream activation of Cdc42

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type

label

Activated ezrin promotes cell ...... downstream activation of Cdc42

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Activated ezrin promotes cell ...... downstream activation of Cdc42

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prefLabel

Activated ezrin promotes cell ...... downstream activation of Cdc42

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Activated ezrin promotes cell ...... downstream activation of Cdc42

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MBC.E06-11-1031

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Molecular Biology of the Cell

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Activated ezrin promotes cell ...... downstream activation of Cdc42

@en

P2093

James Hunt

http://www.w3.org/2001/XMLSchema#string

Melanie D Keppler

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Monique Arpin

http://www.w3.org/2001/XMLSchema#string

Paul Barber

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Rosy Calvert

http://www.w3.org/2001/XMLSchema#string

Soren Prag

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P2860

Ezrin has properties to self-associate at the plasma membrane

Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

Cell migration: integrating signals from front to back

P304

2935-2948

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scholarly article

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10.1091/MBC.E06-11-1031

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8

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18

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Borivoj Vojnovic

Andrew J. Beavil

Simon Ameer-beg

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2007-05-30T00:00:00Z

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17538024

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1949366

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