Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis
about
The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasionMigrastatin analogues target fascin to block tumour metastasisFascin1-dependent Filopodia are required for directional migration of a subset of neural crest cellsThe small GTPase Rap1 promotes cell movement rather than stabilizes adhesion in epithelial cells responding to insulin-like growth factor I.A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.Fascin1 is dispensable for mouse development but is favorable for neonatal survivalFascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture.Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells.Analysis of Fascin-1 in Relation to Gleason Risk Classification and Nuclear ETS-Related Gene Status of Human Prostate Carcinomas: An Immunohistochemical Study of Clinically Annotated Tumours From the Wales Cancer Bank.Fascin expression in colorectal carcinomas.Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.Dephosphorylation-dependent inhibitory activity of juxtanodin on filamentous actin disassembly.The actin-cytoskeleton pathway and its potential role in inflammatory bowel disease-associated human colorectal cancer.Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma.Phosphorylation of fascin decreases the risk of poor survival in patients with esophageal squamous cell carcinoma.A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions.BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-κB Pathway.Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells.Immunohistochemical analysis of oral dysplasia: diagnostic assessment by fascin and podoplanin expressionFascin promotes filopodia formation independent of its role in actin bundling.Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell linesA direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling.Fascin1 promotes cell migration of mature dendritic cells.Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysisPatterned collagen fibers orient branching mammary epithelium through distinct signaling modules.Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain.Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation.β-Catenin/CBP-Dependent Signaling Regulates TGF-β-Induced Epithelial to Mesenchymal Transition of Lens Epithelial CellsFascin1 expression in high-grade serous ovarian carcinoma is a prognostic marker and knockdown of fascin1 suppresses the proliferation of ovarian cancer cells.Protein kinase C, focal adhesions and the regulation of cell migration.Fascin: Invasive filopodia promoting metastasis.The roles of fascins in health and disease.Actin binding proteins: their ups and downs in metastatic life.Fascin1 in carcinomas: Its regulation and prognostic value.The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer.Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.Modulation of the extracellular matrix patterning of thrombospondins by actin dynamics and thrombospondin oligomer state.
P2860
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P2860
Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Dual actin-bundling and protei ...... c and contribute to metastasis
@ast
Dual actin-bundling and protei ...... c and contribute to metastasis
@en
type
label
Dual actin-bundling and protei ...... c and contribute to metastasis
@ast
Dual actin-bundling and protei ...... c and contribute to metastasis
@en
prefLabel
Dual actin-bundling and protei ...... c and contribute to metastasis
@ast
Dual actin-bundling and protei ...... c and contribute to metastasis
@en
P2860
P356
P1476
Dual actin-bundling and protei ...... c and contribute to metastasis
@en
P2093
Yosuke Hashimoto
P2860
P304
P356
10.1091/MBC.E07-02-0157
P577
2007-09-12T00:00:00Z