Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. - Wikidata - wikimedia - TriplyDB

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

http://www.wikidata.org/entity/Q30481799

about

Inherited platelet disorders: toward DNA-based diagnosis The emerging role of oxylipins in thrombosis and diabetes High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs Functional characterization of mutations in inherited human cPLA₂ deficiency Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events.cPLA2 is protective against COX inhibitor-induced intestinal damage.Lipid based therapy for ulcerative colitis-modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation.Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2.Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.Cytosolic phospholipase A₂: physiological function and role in disease.Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome.Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets The involvement of phospholipases A2 in asthma and chronic obstructive pulmonary disease Phospholipase A2 structure/function, mechanism, and signaling.Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins.A PLA1-2 punch regulates the Golgi complex.Cytosolic phospholipase A2α promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.New Concepts and Mechanisms of Platelet Activation Signaling.Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis Lipolysis meets inflammation: arachidonic acid mobilization from fat.The enteropathy of prostaglandin deficiency.Lipoquality control by phospholipase A2 enzymes.Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.Dietary modulation of oxylipins in cardiovascular disease and aging.

P2860

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P2860

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

http://www.wikidata.org/entity/Q30481799

description

2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Inherited human cPLA(2alpha) d ...... ion, and platelet dysfunction.

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Inherited human cPLA(2alpha) d ...... ion, and platelet dysfunction.

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Inherited human cPLA(2alpha) d ...... ion, and platelet dysfunction.

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Inherited human cPLA(2alpha) d ...... ion, and platelet dysfunction.

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Inherited human cPLA(2alpha) d ...... ion, and platelet dysfunction.

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Inherited human cPLA(2alpha) d ...... ion, and platelet dysfunction.

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Journal of Clinical Investigation

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Inherited human cPLA(2alpha) d ...... ion, and platelet dysfunction.

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P2093

David H Adler

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Jason D Morrow

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Jeffrey A Stein

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John A Phillips

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Nathalie Schnetz-Boutaud

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Olivier Boutaud

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Tina Iverson

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P2860

The Protein Data Bank

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism

Raster3D Version 2.0. A program for photorealistic molecular graphics

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies

Low-dose aspirin for the prevention of atherothrombosis

Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

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2121-2131

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10.1172/JCI30473

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6

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118

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Ginger Lohr Milne

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2008-06-01T00:00:00Z

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18451993

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calcium-dependent phospholipase A2 activity

Phospholipase A2 group IVA

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2350426

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